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Selamectin

Name: Selamectin
Brand: TargetMol
SKU: T4059
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4059Cas No. 220119-17-5

Alias UK-124114

Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. In an H. contortus larval development assay, selamectin (0.1 μg/ml) shows the effect of growth inhibition.

Selamectin

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Purity: 99.84%

Catalog No. T4059Alias UK-124114Cas No. 220119-17-5

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$31	In Stock	In Stock
10 mg	$50	In Stock	In Stock
25 mg	$107	In Stock	In Stock
50 mg	$178	In Stock	In Stock
100 mg	$287	In Stock	In Stock
200 mg	$397	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.84%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. In an H. contortus larval development assay, selamectin (0.1 μg/ml) shows the effect of growth inhibition.
Synonyms	UK-124114

Chemical Properties

Molecular Weight	769.96
Formula	C₄₃H₆₃NO₁₁
Cas No.	220119-17-5
Smiles	COC1CC(OC2C(C)\C=C\C=C3/COC4\C(=N\O)C(C)=CC(C(=O)OC5CC(C\C=C2/C)OC2(CCC(C)C(O2)C2CCCCC2)C5)C34O)OC(C)C1O
Relative Density.	1.35 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (116.89 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (4.29 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2988 mL	6.4938 mL	12.9877 mL	64.9384 mL
5 mM	0.2598 mL	1.2988 mL	2.5975 mL	12.9877 mL
10 mM	0.1299 mL	0.6494 mL	1.2988 mL	6.4938 mL
20 mM	0.0649 mL	0.3247 mL	0.6494 mL	3.2469 mL
50 mM	0.0260 mL	0.1299 mL	0.2598 mL	1.2988 mL
100 mM	0.0130 mL	0.0649 mL	0.1299 mL	0.6494 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc