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Cholesterol oxidase
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Catalog No. T76128Cas No. 9028-76-6
Alias ChOx
Cholesterol oxidase is a flavoenzyme that catalyzes the oxidation and isomerization of cholesterol to cholest-4-en-3-one. ChOx, an important virulence factor for Mycobacterium tuberculosis (Mtb), competitively inhibits TLR2 thereby inducing enhanced reactive oxygen species production by macrophages.
Cholesterol oxidase
Cholesterol oxidase
Copy Product Info😃Good
Catalog No. T76128Alias ChOxCas No. 9028-76-6
Cholesterol oxidase is a flavoenzyme that catalyzes the oxidation and isomerization of cholesterol to cholest-4-en-3-one. ChOx, an important virulence factor for Mycobacterium tuberculosis (Mtb), competitively inhibits TLR2 thereby inducing enhanced reactive oxygen species production by macrophages.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 KU | $571 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Color:Yellow
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| Description | Cholesterol oxidase is a flavoenzyme that catalyzes the oxidation and isomerization of cholesterol to cholest-4-en-3-one. ChOx, an important virulence factor for Mycobacterium tuberculosis (Mtb), competitively inhibits TLR2 thereby inducing enhanced reactive oxygen species production by macrophages. |
| Targets&IC50 | HCT116 cells:64.6%(cell viability inhibition at 23 UmL−1), HeLa cells:62.9%(cell viability inhibition at 23 UmL−1), MCF-7 cells:75.3%(cell viability inhibition at 23 UmL−1), HepG2 cells:69.4%(cell viability inhibition at 23 UmL−1) |
| In vitro | Using the MTT assay, Cholesterol oxidase (23 U/mL) showed an inhibition rate of 62.9%-78.7% on cancer cells such as HepG-2 and HCT-116, and an inhibition rate of 57.2% on normal WI-38 cells. Additionally, Cholesterol oxidase can be used to detect cholesterol in serum and food samples (incubated at 37°C for 10 minutes) as well as cholesterol in cells/tissues (using the AmplexRed fluorescence method) [1,2]. |
| Synonyms | ChOx |
| Cas No. | 9028-76-6 |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O: 20 mg/mL, Sonication is recommended. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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