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Cholesterol oxidase
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Catalog No. T76128Cas No. 9028-76-6
Alias ChOx
Cholesterol oxidase is a flavoenzyme that catalyzes the oxidation and isomerization of cholesterol to cholest-4-en-3-one. ChOx, an important virulence factor for Mycobacterium tuberculosis (Mtb), competitively inhibits TLR2 thereby inducing enhanced reactive oxygen species production by macrophages.
Cholesterol oxidase
Cholesterol oxidase
😃Good
Catalog No. T76128Alias ChOxCas No. 9028-76-6
Cholesterol oxidase is a flavoenzyme that catalyzes the oxidation and isomerization of cholesterol to cholest-4-en-3-one. ChOx, an important virulence factor for Mycobacterium tuberculosis (Mtb), competitively inhibits TLR2 thereby inducing enhanced reactive oxygen species production by macrophages.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 KU | $571 | 7-10 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Cholesterol oxidase is a flavoenzyme that catalyzes the oxidation and isomerization of cholesterol to cholest-4-en-3-one. ChOx, an important virulence factor for Mycobacterium tuberculosis (Mtb), competitively inhibits TLR2 thereby inducing enhanced reactive oxygen species production by macrophages. |
| Targets&IC50 | HeLa cells:62.9%(cell viability inhibition at 23 UmL−1), MCF-7 cells:75.3%(cell viability inhibition at 23 UmL−1), HepG2 cells:69.4%(cell viability inhibition at 23 UmL−1), HCT116 cells:64.6%(cell viability inhibition at 23 UmL−1) |
| In vitro | Using the MTT assay, Cholesterol oxidase (23 U/mL) showed an inhibition rate of 62.9%-78.7% on cancer cells such as HepG-2 and HCT-116, and an inhibition rate of 57.2% on normal WI-38 cells. Additionally, Cholesterol oxidase can be used to detect cholesterol in serum and food samples (incubated at 37°C for 10 minutes) as well as cholesterol in cells/tissues (using the AmplexRed fluorescence method) [1,2]. |
| Alias | ChOx |
| Cas No. | 9028-76-6 |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O: 20 mg/mL, Sonication is recommended. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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