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Anti-ADAM17 Polyclonal Antibody
(Synonyms: TNF-alpha-converting enzyme, TNF-alpha convertase, Snake venom-like protease, EC 3.4.24.86, Disintegrin and metalloproteinase domain-containing protein 17, CSVP TACE, CD antigen CD156b, ADAM 17) Copy Product Info
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Synonyms: TNF-alpha-converting enzyme, TNF-alpha convertase, Snake venom-like protease, EC 3.4.24.86, Disintegrin and metalloproteinase domain-containing protein 17, CSVP TACE, CD antigen CD156b, ADAM 17
Catalog No. TMAB-00055 Copy Product Info
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Anti-ADAM17 Polyclonal Antibody is a Rabbit antibody targeting ADAM17. Anti-ADAM17 Polyclonal Antibody can be used in FCM,ICC/IF,IF,IHC-Fr,IHC-P,WB.
Anti-ADAM17 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
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| Description | Anti-ADAM17 Polyclonal Antibody is a Rabbit antibody targeting ADAM17. Anti-ADAM17 Polyclonal Antibody can be used in FCM,ICC/IF,IF,IHC-Fr,IHC-P,WB. |
| Synonyms | TNF-alpha-converting enzyme, TNF-alpha convertase, Snake venom-like protease, EC 3.4.24.86, Disintegrin and metalloproteinase domain-containing protein 17, CSVP TACE, CD antigen CD156b, ADAM 17 |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | WB: 1:500-2000; FCM: 1μg/Test; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; ICC/IF: 1:50-200 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Membrane. |
| Tissue Specificity | Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq]. |
| Immunogen | KLH conjugated synthetic peptide: human ADAM17 |
| Antigen Species | Human |
| Gene Name | ADAM17 |
| Gene ID | |
| Protein Name | Disintegrin and metalloproteinase domain-containing protein 17 |
| Uniprot ID | |
| Biology Area | Response to hypoxia,ADAM protein family,Signal transduction,ADAMs,Hypoxia,Cancer,Neurodegenerative disease,SARS Coronavirus,Alzheimer's disease,Transmembrane,Secreted |
| Function | Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway (By similarity). |
| Molecular Weight | Theoretical: 68/91 kDa. Actual: 100-110 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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