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Angiotensin II (3-8), human TFA

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Catalog No. T10323

Angiotensin II (3-8), human (TFA), is an angiotensin AT1 receptor agonist with reduced activity.

Angiotensin II (3-8), human TFA
Other Forms of Angiotensin II (3-8), human TFA:
Angiotensin II (1-4), human TFATP1661
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Angiotensin II (3-8), human TFA

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Catalog No. T10323
Angiotensin II (3-8), human (TFA), is an angiotensin AT1 receptor agonist with reduced activity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$75InquiryInquiry
10 mg$125InquiryInquiry
25 mg$257InquiryInquiry
50 mgInquiryInquiryInquiry
100 mgInquiryInquiryInquiry
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Angiotensin II (3-8), human (TFA), is an angiotensin AT1 receptor agonist with reduced activity.
In vivo
In anesthetized rats, Human Angiotensin II (3-8) induces endothelium-dependent renal cortical vasodilation. At doses up to 125 pmol/kg, it exerts no cardiovascular effects. However, at doses of 1.25 and 12.5 nmol/kg, it causes dose-dependent elevations in mean arterial blood pressure along with decreases in renal and mesenteric flows and vascular conductances.
Chemical Properties
Molecular Weight888.93
FormulaC42H55F3N8O10
SmilesO=C(O)C(F)(F)F.O=C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC2=CNC=N2)C(N3[C@@H](CCC3)C(N[C@@H](CC4=CC=CC=C4)C(O)=O)=O)=O)=O)=O)[C@H](C(C)C)N
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 50 mg/mL (56.25 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM1.1249 mL5.6247 mL11.2495 mL56.2474 mL
5 mM0.2250 mL1.1249 mL2.2499 mL11.2495 mL
10 mM0.1125 mL0.5625 mL1.1249 mL5.6247 mL
20 mM0.0562 mL0.2812 mL0.5625 mL2.8124 mL
50 mM0.0225 mL0.1125 mL0.2250 mL1.1249 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Angiotensin II , human TFAAngiotensin II (38), human TFAAngiotensin II (3 8), human TFAAngiotensin AT1 receptor
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