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LY3372689

Name: LY3372689
Brand: TargetMol
SKU: T61661
Price: 100 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Formulaic Ia) Copy Product Info

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Synonyms: Formulaic Ia

Catalog No. T61661 Copy Product Info

Purity: 99.53%

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LY3372689 (Formulaic Ia) is an oral, highly selective, CNS-permeable O-GlcNAcase (OGA) inhibitor. LY3372689 exerts a neuroprotective effect by inhibiting OGA enzymatic activity, increasing the O-GlcNAc glycosylation level of tau protein, and thereby reducing abnormal tau phosphorylation and the formation of neurofibrillary tangles. LY3372689 can be used in research on tau-related diseases, including Alzheimer’s disease.

Cas No. 2241514-56-5

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Pack Size	Price	USA Stock	Global Stock
1 mg	$100	In Stock	In Stock
5 mg	$247	In Stock	In Stock
10 mg	$372	In Stock	In Stock
25 mg	$668	In Stock	In Stock
50 mg	$985	In Stock	In Stock
100 mg	$1,490	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$272	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.53%

ee:100%

Appearance:Solid

Color:Yellow

Resource Download

COA CSFC FNMR HNMR LCMS

Product Introduction

Bioactivity

Description	LY3372689 (Formulaic Ia) is an oral, highly selective, CNS-permeable O-GlcNAcase (OGA) inhibitor. LY3372689 exerts a neuroprotective effect by inhibiting OGA enzymatic activity, increasing the O-GlcNAc glycosylation level of tau protein, and thereby reducing abnormal tau phosphorylation and the formation of neurofibrillary tangles. LY3372689 can be used in research on tau-related diseases, including Alzheimer’s disease.
In vitro	Methods: 300-μm-thick mouse hippocampal slices were treated with 10 μM LY3372689 or DMSO for 4 h. Whole-cell patch-clamp recordings were performed on CA1 neurons to assess paired-pulse facilitation (PPF) and paired-pulse depression (PPD). Results: LY3372689 significantly reduced PPF and PPD, impairing short-term synaptic plasticity. [3]
In vivo	Methods: Sprague Dawley rats were administered a single oral dose of 0.001–3 mg/kg. Plasma concentrations and enzyme occupancy rates were measured post-administration. Results: The highest dose group treated with LY3372689 achieved over 90% EO and a maximum OGA enzyme occupancy of 98%. [1]
Synonyms	Formulaic Ia

Chemical Properties

Molecular Weight	383.44
Formula	C₁₆H₂₂FN₅O₃S
Cas No.	2241514-56-5
Smiles	C[C@H]1C[C@H](CCN1Cc1sc(NC(C)=O)nc1F)OCc1noc(C)n1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (586.79 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6080 mL	13.0398 mL	26.0797 mL	130.3985 mL
5 mM	0.5216 mL	2.6080 mL	5.2159 mL	26.0797 mL
10 mM	0.2608 mL	1.3040 mL	2.6080 mL	13.0398 mL
20 mM	0.1304 mL	0.6520 mL	1.3040 mL	6.5199 mL
50 mM	0.0522 mL	0.2608 mL	0.5216 mL	2.6080 mL
100 mM	0.0261 mL	0.1304 mL	0.2608 mL	1.3040 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.