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Clopidogrel

Name: Clopidogrel
Brand: TargetMol
SKU: T0182
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0182Cas No. 113665-84-2

Alias SR-25990C, (S)-Clopidogrel

Clopidogrel (SR-25990C), a P2Y12 receptor antagonist, decreases platelet aggregation.

Clopidogrel

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Purity: 98.83%

Catalog No. T0182Alias SR-25990C, (S)-ClopidogrelCas No. 113665-84-2

Clopidogrel (SR-25990C), a P2Y12 receptor antagonist, decreases platelet aggregation.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$41	In Stock	In Stock
200 mg	$58	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.83%

Color:Transparent to Yellow

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COA HNMR LCMS

Product Introduction

Clopidogrel AI Summary

Clopidogrel is a multifaceted bioactive substance demonstrating significant inhibitory, modulatory, and cytotoxic properties across various biological targets. It acts as a potent inhibitor of human recombinant carboxylesterase 1 (CES1) with a Km value of 55700 nM and a pKm value of 4.25. In the field of enzymatic inhibition, it also shows mechanism-based inhibition of cytochrome P450 2B6, with Ki values of 500 nM and 1100 nM and Kinact values of 0.35 min^-1 and 0.15 min^-1, respectively. It has considerable activity against the serotonin transporter (SERT), with an IC50 of 562 nM and a Ki of 299 nM. The compound exhibits noteworthy bioactivity in various assays: - It inhibits the Influenza NS1 protein function with a potency of 19952.6 nM. - It demonstrates delayed death inhibition of the malarial parasite plastid with potencies of 8275.3 nM (96-hour incubation) and 11689.1 nM (48-hour incubation). - It functions as an inhibitor of HP1-beta chromodomain interactions with methylated histone tails with a potency of 89125.1 nM. Furthermore, Clopidogrel exhibits pharmacokinetic properties in Sprague-Dawley rats, with a maximum concentration (Cmax) of 21.53 nM reached at 0.583 hours post-administration, a half-life of 2.48 hours, and an area under the curve (AUC) of 32200 ng.hr.mL^-1. It shows a high clearance rate in human liver microsomes exceeding 300 mL.min^-1.g^-1, indicating rapid metabolism. In antiplatelet and antithrombotic assays, the compound effectively inhibits ADP-induced platelet aggregation in rabbit platelets and demonstrates significant antithrombotic activity in rodent models, reducing thrombus weight by 67% in the FeCl2-induced thrombosis model. Additionally, it prolongs bleeding time in various animal models, indicative of its anticoagulant potential. On the toxicity front, Clopidogrel has shown moderate hepatotoxicity, as evidenced by elevated serum ALT and AST enzyme levels, and significant impacts on hepatotoxicity indices. It also shows intravital toxicity by prolonging mesenteric and cuticle bleeding time in rat models. The compound exhibits broad-spectrum antibacterial activity, particularly against methicillin-resistant Staphylococcus aureus (MRSA) USA300, and antifungal activity against Candida albicans and Cryptococcus neoformans. However, its antiviral activity against SARS-CoV-2 is limited, with low inhibition efficacy. Overall, Clopidogrel’s diverse bioactivities suggest its potential as a valuable candidate in pharmaceutical research while underscoring the necessity for careful evaluation of its pharmacodynamics and toxicological profiles in further studies..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Clopidogrel (SR-25990C), a P2Y12 receptor antagonist, decreases platelet aggregation.
Synonyms	SR-25990C, (S)-Clopidogrel

Chemical Properties

Molecular Weight	321.82
Formula	C₁₆H₁₆ClNO₂S
Cas No.	113665-84-2
Smiles	COC(=O)[C@@H](N1CCc2sccc2C1)c1ccccc1Cl
Relative Density.	1.317g/cm3

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 40 mg/mL (124.29 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.21 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1073 mL	15.5366 mL	31.0733 mL	155.3664 mL
5 mM	0.6215 mL	3.1073 mL	6.2147 mL	31.0733 mL
10 mM	0.3107 mL	1.5537 mL	3.1073 mL	15.5366 mL
20 mM	0.1554 mL	0.7768 mL	1.5537 mL	7.7683 mL
50 mM	0.0621 mL	0.3107 mL	0.6215 mL	3.1073 mL
100 mM	0.0311 mL	0.1554 mL	0.3107 mL	1.5537 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc