This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
Indomethacin sodium
Catalog No. T61606 CAS
7681-54-1
Indomethacin sodium, a powerful and orally active inhibitor of COX1/2, exhibits IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Apart from its potent anti-inflammatory effects, this compound possesses notable anticancer and anti-infective activities. Since it has such versatile attributes, it finds useful applicability in cancer, inflammation, and viral infection research [1] [2] [3].
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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
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Biological Description
Chemical Properties
Storage
& Solubility Information
Description
Indomethacin sodium, a powerful and orally active inhibitor of COX1/2, exhibits IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Apart from its potent anti-inflammatory effects, this compound possesses notable anticancer and anti-infective activities. Since it has such versatile attributes, it finds useful applicability in cancer, inflammation, and viral infection research [1] [2] [3].
In vitro
Indomethacin (Indometacin) sodium, across concentrations ranging from 0 to 150 μM administered over 24 hours, exhibits significant anticancer effects in vitro on 3LL-D122 cells, a highly metastatic variant of mouse Lewis lung carcinoma cells [2]. Additionally, this compound, at concentrations up to 1000 μM, activates PKR leading to phosphorylation of eIF2α. This process halts the translation of viral proteins, effectively inhibiting virus replication with an IC50 value of 2μM, thereby protecting the host cells from viral damage [3]. Cell viability assays on the 3LL-D122 line reveal that cell viability is inhibited at 20 mM, achieving a 50% inhibition rate at 60 nM. Furthermore, cell cycle analysis after 24 hours of exposure to 0, 30, and 80μM concentrations shows a decrease in cells at the G2/M phase and an increase at the G1 phase, indicating significant alterations in cell cycle progression induced by Indomethacin sodium [2].
In vivo
Administered orally to male Sprague-Dawley rats at dosages ranging from 0.01 to 10 mg/kg for three hours, Indomethacin (Indometacin) sodium dose-dependently mitigated carrageenan-induced paw edema and hyperalgesia, evidencing an inhibition of reactive inflammation and pain sensitivity [1]. Similarly, a daily oral dose of 10 mg/mL Indomethacin (Indometacin) sodium for 29 days in male C57BL/6J mice effectively impeded tumor growth in vivo, indicating its potential anti-tumoral properties [2]. Specifically, in the Sprague-Dawley rat model, the administration led to a significant reduction in both carrageenan-induced edema (Effective Dose, ED50 = 2.0 mg/kg) and hyperalgesia (ED 50 = 1.5 mg/kg), demonstrating dose-responsive therapeutic effects. In the C57BL/6J mouse model, the prolonged treatment notably delayed tumor emergence and slowed the initial rate of tumor expansion in the footpad.
Molecular Weight
379.77
Formula
C19H15ClNNaO4
CAS No.
7681-54-1
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dose Conversion
You can also refer to dose conversion for different animals.
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Method for preparing DMSO master liquid: mg
drug pre-dissolved in μL DMSO (Master liquid concentration
mg/mL),
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL PEG300, mix and clarify, next add μL
Tween 80,mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL Corn oil,mix and clarify.
Note:
Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.