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ARM1

Name: ARM1
Brand: TargetMol
SKU: T21859
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21859Cas No. 68729-05-5

ARM1 is a potent inhibitor of aminopeptidase and epoxide hydrolase. The IC50 values are 7.61 µM for aminopeptidase and 12.4 µM for epoxide hydrolase.

ARM1

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Purity: 99.36%

Catalog No. T21859Cas No. 68729-05-5

ARM1 is a potent inhibitor of aminopeptidase and epoxide hydrolase. The IC50 values are 7.61 µM for aminopeptidase and 12.4 µM for epoxide hydrolase.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$43	In Stock	In Stock
10 mg	$68	In Stock	In Stock
25 mg	$123	In Stock	In Stock
50 mg	$179	In Stock	In Stock
100 mg	$268	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.36%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

ARM1 AI Summary

ARM1 demonstrates significant bioactivity by binding to and inhibiting human LTA4H, with Kd values ranging from 130.0 nM to 310.0 nM at different temperatures. It shows competitive inhibition with a Ki of 360.0 nM and an IC50 of 400.0 nM, also causing changes in the protein's melting temperature. The compound exhibits cytotoxicity against human TIG1, HCT116, and HF19 cells with IC50 values of 84280.0 nM, 30540.0 nM, and >100000.0 nM, respectively, and has a selectivity index of 2.76. It inhibits the aminopeptidase and epoxide hydrolase activities of recombinant C-terminal His-tagged human LTA4H with IC50 values of 7610.0 nM and 12400.0 nM, respectively. Moreover, it activates LTA4H's aminopeptidase activity, affecting catalytic parameters like Kcat and Km, and influences the efficiency of substrate utilization. ARM1 also exhibits mild antiviral activity against SARS-CoV-2, inhibiting 3CL-Pro protease by 9.67% at 20 µM and reducing SARS-CoV-2-induced cytotoxicity in VERO-6 cells by -0.04% at 10 µM, though the latter inhibition percentage is very low..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	ARM1 is a potent inhibitor of aminopeptidase and epoxide hydrolase. The IC50 values are 7.61 µM for aminopeptidase and 12.4 µM for epoxide hydrolase.
Targets&IC50	Aminopeptidase:7.61 µM, Epoxide hydrolase:12.4 µM

Chemical Properties

Molecular Weight	266.36
Formula	C₁₆H₁₄N₂S
Cas No.	68729-05-5
Smiles	Nc1nc(cs1)-c1ccc(Cc2ccccc2)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (938.58 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7543 mL	18.7716 mL	37.5432 mL	187.7159 mL
5 mM	0.7509 mL	3.7543 mL	7.5086 mL	37.5432 mL
10 mM	0.3754 mL	1.8772 mL	3.7543 mL	18.7716 mL
20 mM	0.1877 mL	0.9386 mL	1.8772 mL	9.3858 mL
50 mM	0.0751 mL	0.3754 mL	0.7509 mL	3.7543 mL
100 mM	0.0375 mL	0.1877 mL	0.3754 mL	1.8772 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc