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TOPRelated productsBioactivityChemical infoStorage&SolubilityCalculator

2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide

🥰Excellent
Catalog No. T22338Cas No. 1258292-64-6
Alias GDC046

2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity, physicochemical properties and pharmacokinetic profile.

2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide

2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide

🥰Excellent
Purity: 98.77%
Catalog No. T22338Alias GDC046Cas No. 1258292-64-6
2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity, physicochemical properties and pharmacokinetic profile.
Pack SizePriceAvailabilityQuantity
1 mg$43In Stock
5 mg$100In Stock
10 mg$165In Stock
25 mg$315In Stock
50 mg$489In Stock
100 mg$759In Stock
200 mg$987In Stock
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Purity:98.77%
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Product Introduction

Bioactivity
Description
2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity, physicochemical properties and pharmacokinetic profile.
Targets&IC50
TYK2:4.8 nM (Ki), JAK2:0.7 nM (Ki), JAK1:0.7 nM (Ki), JAK3:0.4 nM (Ki)
SynonymsGDC046
Chemical Properties
Molecular Weight350.2
FormulaC16H13Cl2N3O2
Cas No.1258292-64-6
SmilesClc1cccc(Cl)c1C(=O)Nc1ccnc(NC(=O)C2CC2)c1
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 3.51 mg/mL (10.02 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8555 mL14.2776 mL28.5551 mL142.7756 mL
5 mM0.5711 mL2.8555 mL5.7110 mL28.5551 mL
10 mM0.2856 mL1.4278 mL2.8555 mL14.2776 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

TYK2Janus kinaseJAK3JAK2JAK1JAKInhibitorinhibitinflammatoryIL-23IL-12IBDGDC-046GDC 046diseasesbowel2,6DichloroN(2(cyclopropanecarboxamido)pyridin4yl)benzamide2,6 Dichloro N (2 (cyclopropanecarboxamido)pyridin 4 yl)benzamide
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