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zapnometinib

Name: zapnometinib
Brand: TargetMol
SKU: T9321
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9321Cas No. 303175-44-2

Alias PD0184264, ATR-002, 3,4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid, 2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acid

Zapnometinib (ATR-002) is a MEK inhibitor.

zapnometinib

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Purity: 99.67%

Catalog No. T9321Alias PD0184264, ATR-002, 3,4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid, 2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acidCas No. 303175-44-2

Zapnometinib (ATR-002) is a MEK inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$40	In Stock	In Stock
10 mg	$60	In Stock	In Stock
25 mg	$73	In Stock	In Stock
50 mg	$139	In Stock	In Stock
100 mg	$272	In Stock	In Stock
200 mg	$396	-	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.67%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Zapnometinib (ATR-002) is a MEK inhibitor.
Targets&IC50	MEK:5.7 nM
In vitro	Zapnometinib inhibits MEK, with IC50s of 30.96 nM, 357 nM, and 15 nM in cell free kinase assay, A549, MDCK cells and human PBMCs[1].Zapnometinib reduces the viral titers of the IV H1N1pdm09, H3N2[1].
In vivo	Zapnometinib exhibits AUC values of 860.02 and 1953.68 μg?h/mL in mice by i.v. or oral route, respectively[1].Zapnometinib reduces the lung virus titers and enhances survival of mice after lethal H1N1pdm09 infection[1].
Synonyms	PD0184264, ATR-002, 3,4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid, 2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acid

Chemical Properties

Molecular Weight	409.55
Formula	C₁₃H₇ClF₂INO₂
Cas No.	303175-44-2
Smiles	OC(=O)c1ccc(F)c(F)c1Nc1ccc(I)cc1Cl
Relative Density.	1.946 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (146.5 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.88 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4417 mL	12.2085 mL	24.4170 mL	122.0852 mL
5 mM	0.4883 mL	2.4417 mL	4.8834 mL	24.4170 mL
10 mM	0.2442 mL	1.2209 mL	2.4417 mL	12.2085 mL
20 mM	0.1221 mL	0.6104 mL	1.2209 mL	6.1043 mL
50 mM	0.0488 mL	0.2442 mL	0.4883 mL	2.4417 mL
100 mM	0.0244 mL	0.1221 mL	0.2442 mL	1.2209 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc