Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Zapnometinib (ATR-002) is a MEK inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 47.00 | |
10 mg | In stock | $ 72.00 | |
25 mg | In stock | $ 87.00 | |
50 mg | In stock | $ 168.00 | |
100 mg | In stock | $ 323.00 | |
200 mg | In stock | $ 487.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 60.00 |
Description | Zapnometinib (ATR-002) is a MEK inhibitor. |
Targets&IC50 | MEK:5.7 nM |
In vitro | Zapnometinib inhibits MEK, with IC50s of 30.96 nM, 357 nM, and 15 nM in cell free kinase assay, A549, MDCK cells and human PBMCs[1].Zapnometinib reduces the viral titers of the IV H1N1pdm09, H3N2[1]. |
In vivo | Zapnometinib exhibits AUC values of 860.02 and 1953.68 μg?h/mL in mice by i.v. or oral route, respectively[1].Zapnometinib reduces the lung virus titers and enhances survival of mice after lethal H1N1pdm09 infection[1]. |
Synonyms | ATR-002, 3,4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid, PD0184264, 2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acid |
Molecular Weight | 409.55 |
Formula | C13H7ClF2INO2 |
CAS No. | 303175-44-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (146.50 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
zapnometinib 303175-44-2 MAPK Microbiology/Virology Antibacterial MEK Influenza Virus antiviral virus MAPKK Bacterial PD-0184264 CI-1040 ATR 002 Inhibitor ATR-002 Mitogen-activated protein kinase kinase antibacterial 3,4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid inhibit ATR002 influenza PD0184264 PD 0184264 2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acid MAP2K inhibitor