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zapnometinib

🥰Excellent
Catalog No. T9321Cas No. 303175-44-2
Alias PD0184264, ATR-002, 3,4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid, 2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acid

Zapnometinib (ATR-002) is a MEK inhibitor.

zapnometinib

zapnometinib

🥰Excellent
Purity: 99.67%
Catalog No. T9321Alias PD0184264, ATR-002, 3,4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid, 2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acidCas No. 303175-44-2
Zapnometinib (ATR-002) is a MEK inhibitor.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$40In StockIn Stock
10 mg$60In StockIn Stock
25 mg$73In StockIn Stock
50 mg$139In StockIn Stock
100 mg$272In StockIn Stock
200 mg$396-In Stock
1 mL x 10 mM (in DMSO)$46In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.67%
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Product Introduction

Bioactivity
Description
Zapnometinib (ATR-002) is a MEK inhibitor.
Targets&IC50
MEK:5.7 nM
In vitro
Zapnometinib inhibits MEK, with IC50s of 30.96 nM, 357 nM, and 15 nM in cell free kinase assay, A549, MDCK cells and human PBMCs[1].Zapnometinib reduces the viral titers of the IV H1N1pdm09, H3N2[1].
In vivo
Zapnometinib exhibits AUC values of 860.02 and 1953.68 μg?h/mL in mice by i.v. or oral route, respectively[1].Zapnometinib reduces the lung virus titers and enhances survival of mice after lethal H1N1pdm09 infection[1].
SynonymsPD0184264, ATR-002, 3,4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid, 2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acid
Chemical Properties
Molecular Weight409.55
FormulaC13H7ClF2INO2
Cas No.303175-44-2
SmilesOC(=O)c1ccc(F)c(F)c1Nc1ccc(I)cc1Cl
Relative Density.1.946 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 60 mg/mL (146.5 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.88 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4417 mL12.2085 mL24.4170 mL122.0852 mL
5 mM0.4883 mL2.4417 mL4.8834 mL24.4170 mL
10 mM0.2442 mL1.2209 mL2.4417 mL12.2085 mL
20 mM0.1221 mL0.6104 mL1.2209 mL6.1043 mL
50 mM0.0488 mL0.2442 mL0.4883 mL2.4417 mL
100 mM0.0244 mL0.1221 mL0.2442 mL1.2209 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

zapnometinibvirusPD-0184264PD 0184264Mitogen-activated protein kinase kinaseMEKMAPKKMAP2KInhibitorinhibitInfluenzaVirusInfluenza VirusinfluenzaCI-1040BacterialATR002ATR 002antiviralantibacterial
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