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zapnometinib

Name: zapnometinib
Brand: TargetMol
SKU: T9321
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T9321Cas No. 303175-44-2

Alias PD0184264, ATR-002, 3,4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid, 2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acid

Zapnometinib (ATR-002) is a MEK inhibitor.

zapnometinib

🥰Excellent

Purity: 99.67%

Catalog No. T9321Alias PD0184264, ATR-002, 3,4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid, 2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acidCas No. 303175-44-2

Zapnometinib (ATR-002) is a MEK inhibitor.

Pack Size	Price	Availability
5 mg	$40	In Stock
10 mg	$60	In Stock
25 mg	$73	In Stock
50 mg	$139	In Stock
100 mg	$272	In Stock
200 mg	$396	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock

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Batch Information

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Purity:99.67%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Zapnometinib (ATR-002) is a MEK inhibitor.
Targets&IC50	MEK:5.7 nM
In vitro	Zapnometinib inhibits MEK, with IC50s of 30.96 nM, 357 nM, and 15 nM in cell free kinase assay, A549, MDCK cells and human PBMCs[1].Zapnometinib reduces the viral titers of the IV H1N1pdm09, H3N2[1].
In vivo	Zapnometinib exhibits AUC values of 860.02 and 1953.68 μg?h/mL in mice by i.v. or oral route, respectively[1].Zapnometinib reduces the lung virus titers and enhances survival of mice after lethal H1N1pdm09 infection[1].
Synonyms	PD0184264, ATR-002, 3,4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid, 2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acid

Chemical Properties

Molecular Weight	409.55
Formula	C₁₃H₇ClF₂INO₂
Cas No.	303175-44-2
Smiles	OC(=O)c1ccc(F)c(F)c1Nc1ccc(I)cc1Cl
Relative Density.	1.946 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (146.5 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4417 mL	12.2085 mL	24.4170 mL	122.0852 mL
5 mM	0.4883 mL	2.4417 mL	4.8834 mL	24.4170 mL
10 mM	0.2442 mL	1.2209 mL	2.4417 mL	12.2085 mL
20 mM	0.1221 mL	0.6104 mL	1.2209 mL	6.1043 mL
50 mM	0.0488 mL	0.2442 mL	0.4883 mL	2.4417 mL
100 mM	0.0244 mL	0.1221 mL	0.2442 mL	1.2209 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc