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TXNIP-IN-1

🥰Excellent
Catalog No. T13230Cas No. 1268955-50-5

TXNIP-IN-1 is an inhibitor of the TXNIP-TRX complex and used in the research of TXNIP-TRX complex associated metabolic disorder (diabetes), cardiovascular disease, or inflammatory disease.

TXNIP-IN-1
Other Forms of TXNIP-IN-1:
(S)-TXNIP-IN-1T128171212421-96-9
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TXNIP-IN-1

🥰Excellent
Purity: 99.11%
Catalog No. T13230Cas No. 1268955-50-5
TXNIP-IN-1 is an inhibitor of the TXNIP-TRX complex and used in the research of TXNIP-TRX complex associated metabolic disorder (diabetes), cardiovascular disease, or inflammatory disease.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$135In StockIn Stock
5 mg$289In StockIn Stock
10 mg$438In StockIn Stock
25 mg$726In StockIn Stock
50 mg$987In StockIn Stock
100 mg$1,380In StockIn Stock
500 mg$2,770In StockIn Stock
1 mL x 10 mM (in DMSO)$373In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.11%
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Product Introduction

Bioactivity
Description
TXNIP-IN-1 is an inhibitor of the TXNIP-TRX complex and used in the research of TXNIP-TRX complex associated metabolic disorder (diabetes), cardiovascular disease, or inflammatory disease.
In vitro
TXNIP-IN-1 bocks high glucose (HG induced) TXNIP-TRX complex formation.In monocytes, TXNIP-IN-1 (1.25-5 μM) reduces HG-induced expression of TNF . In THP1 cells,TXNIP-IN-1 (1.25-5 μM; 72 hours) inhibits TXNIP mRNA expression . TXNIP-IN-1 (0.3-10 μM; 72 hours) inhibits TXNIP mRNA expression in murine RAW macrophages. In MIN6 cells, TXNIP-IN-1 (5-20 μM; 72 hours) decreases TXNIP but not TNF-alpha mRNA levels . TXNIP-IN-1 (0.62-5 μM; 72 hours) affects TXNIP and TNF-alpha mRNA expression in human pancreas 1.1B4 beta cells. TXNIP-IN-1 (5 μM; 16-72 hours) inhibits c-TRX interaction in THP1 cells cultured in 25mM glucose. TXNIP-IN-1 targets TXNIP mRNA in human pancreatic islets.
Chemical Properties
Molecular Weight248.23
FormulaC12H12N2O4
Cas No.1268955-50-5
SmilesCC(C)C(N1C(=O)c2ccncc2C1=O)C(O)=O
Relative Density.1.410 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (161.14 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.06 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.0285 mL20.1426 mL40.2852 mL201.4261 mL
5 mM0.8057 mL4.0285 mL8.0570 mL40.2852 mL
10 mM0.4029 mL2.0143 mL4.0285 mL20.1426 mL
20 mM0.2014 mL1.0071 mL2.0143 mL10.0713 mL
50 mM0.0806 mL0.4029 mL0.8057 mL4.0285 mL
100 mM0.0403 mL0.2014 mL0.4029 mL2.0143 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Keywords

TXNIP-TRX complexTXNIP-IN-1TXNIPIN1TXNIP IN 1TXNIPTRXthioredoxin-interactingthioredoxinproteinInhibitorinhibitdiabetes
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