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Conatumumab
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Catalog No. T76787Cas No. 896731-82-1
Alias TRAIL-R2 mAb, AMG 655
Conatumumab (AMG 655) is a monoclonal agonist antibody targeting human death receptor 5 [DR5, TRAILR2] with a dissociation constant (Kd) of 1 nM for long DR5 and 0.8 nM for short DR5. It induces apoptosis in various tumor types through caspase activation and can be used to study advanced solid tumors.
Conatumumab
Conatumumab
😃Good
Catalog No. T76787Alias TRAIL-R2 mAb, AMG 655Cas No. 896731-82-1
Conatumumab (AMG 655) is a monoclonal agonist antibody targeting human death receptor 5 [DR5, TRAILR2] with a dissociation constant (Kd) of 1 nM for long DR5 and 0.8 nM for short DR5. It induces apoptosis in various tumor types through caspase activation and can be used to study advanced solid tumors.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $378 | In Stock | In Stock | |
| 5 mg | $955 | In Stock | In Stock | |
| 10 mg | $1,530 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Conatumumab (AMG 655) is a monoclonal agonist antibody targeting human death receptor 5 [DR5, TRAILR2] with a dissociation constant (Kd) of 1 nM for long DR5 and 0.8 nM for short DR5. It induces apoptosis in various tumor types through caspase activation and can be used to study advanced solid tumors. |
| Targets&IC50 | DR5:<1 nM |
| In vitro | Activated caspase-3/7 in Colo205, H-2122, and MiaPaCa2 cells, conatumumab (0-10 μg/mL, 4 h) exhibited this effect[2]. Reducing the cell viability of sensitive tumor cell lines (Colo205, H-2122, and MiaPaCa2 cells), conatumumab (0-10 μg/mL, 24 h) demonstrated this activity[2]. |
| In vivo | In mice with Colo205, H2122, or MiaPaCa2/T2 xenograft tumors, Conatumumab (0-100 μg, intraperitoneal injection, twice a week) inhibited tumor growth[2]. Conatumumab (2.5 μg, i.p., 3 times a week) enhances the antitumor activity of chemotherapeutic drugs (CPT11) (80 mg/kg) in Colo 205 xenografts[2]. |
| Synonyms | TRAIL-R2 mAb, AMG 655 |
| Reactivity | Human |
| Verified Activity | Immobilized Cynomolgus DR5 Protein (ECD, His) at 2 μg/mL (30 μL/well) can bind Conatumumab. The EC50 is 111.9 ng/mL.  |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | TNFRSF10B/TRAILR2/CD262 |
| Molecular Weight | 145.44 kDa |
| Cas No. | 896731-82-1 |
| Color | Transparent |
| Appearance | Liquid |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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