Shopping Cart
- Remove All
Your shopping cart is currently empty
Conatumumab
🥰Excellent
Catalog No. T76787Cas No. 896731-82-1
Alias TRAIL-R2 mAb, AMG 655
Conatumumab (AMG 655) is a monoclonal agonist antibody targeting human death receptor 5 [DR5, TRAILR2] with a dissociation constant (Kd) of 1 nM for long DR5 and 0.8 nM for short DR5. It induces apoptosis in various tumor types through caspase activation and can be used to study advanced solid tumors.
Conatumumab
Conatumumab
🥰Excellent
Catalog No. T76787Alias TRAIL-R2 mAb, AMG 655Cas No. 896731-82-1
Conatumumab (AMG 655) is a monoclonal agonist antibody targeting human death receptor 5 [DR5, TRAILR2] with a dissociation constant (Kd) of 1 nM for long DR5 and 0.8 nM for short DR5. It induces apoptosis in various tumor types through caspase activation and can be used to study advanced solid tumors.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $378 | In Stock | |
| 5 mg | $955 | In Stock | |
| 10 mg | $1,530 | In Stock |
Add to Cart
Add to Quotation
Bulk & Custom
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
View MoreBatch Information
Select Batch
Concentration:3.43 mg/mL
Purity:> 95%
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | Conatumumab (AMG 655) is a monoclonal agonist antibody targeting human death receptor 5 [DR5, TRAILR2] with a dissociation constant (Kd) of 1 nM for long DR5 and 0.8 nM for short DR5. It induces apoptosis in various tumor types through caspase activation and can be used to study advanced solid tumors. |
| Targets&IC50 | DR5:<1 nM |
| In vitro | Activated caspase-3/7 in Colo205, H-2122, and MiaPaCa2 cells, conatumumab (0-10 μg/mL, 4 h) exhibited this effect[2]. Reducing the cell viability of sensitive tumor cell lines (Colo205, H-2122, and MiaPaCa2 cells), conatumumab (0-10 μg/mL, 24 h) demonstrated this activity[2]. |
| In vivo | In mice with Colo205, H2122, or MiaPaCa2/T2 xenograft tumors, Conatumumab (0-100 μg, intraperitoneal injection, twice a week) inhibited tumor growth[2]. Conatumumab (2.5 μg, i.p., 3 times a week) enhances the antitumor activity of chemotherapeutic drugs (CPT11) (80 mg/kg) in Colo 205 xenografts[2]. |
| Synonyms | TRAIL-R2 mAb, AMG 655 |
| Molecular Weight | 145 kDa (average) |
| Cas No. | 896731-82-1 |
| Color | Transparent |
| Appearance | Liquid |
Storage & Solubility Information
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Sci Citations
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy Conatumumab | purchase Conatumumab | Conatumumab cost | order Conatumumab | Conatumumab in vivo | Conatumumab in vitro | Conatumumab molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.