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YUM70

Name: YUM70
Brand: TargetMol
SKU: T8901
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8901Cas No. 423145-35-1

YUM70 is a potent and selective inhibitor of glucose-regulated protein 78 (GRP78), with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein. It induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer.

YUM70

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Purity: 97.25%

Catalog No. T8901Cas No. 423145-35-1

Pack Size	Price	Availability
1 mg	$41	In Stock
5 mg	$88	In Stock
10 mg	$137	In Stock
25 mg	$278	In Stock
50 mg	$410	In Stock
100 mg	$583	In Stock
200 mg	$789	In Stock
1 mL x 10 mM (in DMSO)	$97	In Stock

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Purity:97.25%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	YUM70 is a potent and selective inhibitor of glucose-regulated protein 78 (GRP78), with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein. It induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer.
Targets&IC50	GRP78:1.5 μM
In vitro	YUM70, inhibited pancreatic cancer cell growth in vitro.YUM70 directly bound GRP78 and inactivated its function, resulting in ER stress-mediated apoptosis.?A YUM70 analog conjugated with BODIPY show co-localization of the compound with GRP78 in the ER.
In vivo	YUM70 in vivo efficacy in a pancreatic cancer xenograft model with no toxicity to normal tissues.YUM70 is a novel inducer of ER stress with preclinical efficacy as a monotherapy or in combination with topoisomerase and HDAC inhibitors in pancreatic cancer.

Chemical Properties

Molecular Weight	398.84
Formula	C₂₁H₁₉ClN₂O₄
Cas No.	423145-35-1
Smiles	CCCC(=O)NC(c1ccc2OCOc2c1)c1cc(Cl)c2cccnc2c1O
Relative Density.	1.373 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (250.73 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5073 mL	12.5364 mL	25.0727 mL	125.3636 mL
5 mM	0.5015 mL	2.5073 mL	5.0145 mL	25.0727 mL
10 mM	0.2507 mL	1.2536 mL	2.5073 mL	12.5364 mL
20 mM	0.1254 mL	0.6268 mL	1.2536 mL	6.2682 mL
50 mM	0.0501 mL	0.2507 mL	0.5015 mL	2.5073 mL
100 mM	0.0251 mL	0.1254 mL	0.2507 mL	1.2536 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc