TROP-2 Protein, Human, Recombinant (His & hFc)

Catalog No. TMPY-00946 Copy Product Info

TROP-2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 55.7 kDa and the accession number is P09758.

TROP-2 Protein, Human, Recombinant (His & hFc)

Catalog No. TMPY-00946

Copy Product Info

TROP-2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 55.7 kDa and the accession number is P09758.

Pack Size	Price	USA Stock	Global Stock
5 μg	$44	7-10 days	7-10 days
10 μg	$68	7-10 days	7-10 days
20 μg	$108	7-10 days	7-10 days
50 μg	$215	7-10 days	7-10 days
100 μg	$413	7-10 days	7-10 days
200 μg	$629	7-10 days	7-10 days
500 μg	$1,320	7-10 days	7-10 days
1 mg	$2,700	7-10 days	7-10 days

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Biological Activity	Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells. When cells are added to coated plates (10μg/ml,100μl/well), approximately 55%-70% will adhere specifically.
Description	TROP-2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 55.7 kDa and the accession number is P09758.
Species	Human
Expression System	HEK293 Cells
Tag	His, hFc
Accession Number	P09758
Synonyms	tumor-associated calcium signal transducer 2,TROP-2,TROP2,TACD2,M1S1,GP50,GA733-1,GA7331,EGP-1,EGP1
Construction	A DNA sequence encoding the extracellular domain (Met 1-Thr 274) of human TROP2 (NP_002344.2) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus. Predicted N terminal: His 27
Protein Purity	> 98 % as determined by SDS-PAGE
Molecular Weight	55.7 kDa (predicted); 65-75 kDa (reducing condition, due to glycosylation)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Research Background	TROP-2, also referred to as tumor-associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, which are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate.