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Urea

Name: Urea
Brand: TargetMol
SKU: T0738
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0738Cas No. 57-13-6

Alias Ureophil, E-Cardamoni, Carbonyldiamide, Carbamide

Urea (Carbonyldiamide) is formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end metabolite of protein catabolism and accounts for about one-half of the total urinary solids.

Urea

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Purity: 99.44%

Catalog No. T0738Alias Ureophil, E-Cardamoni, Carbonyldiamide, CarbamideCas No. 57-13-6

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$30	In Stock	In Stock
100 mg	$42	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.44%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Urea AI Summary

Urea exhibits diverse bioactivities and physicochemical properties, making it a compound of interest in various studies. It has an effective permeability of Peff = 1.4 in humans and a high absorption rate (Fa = 100.0%) in the human intestine. The compound features a range of partition coefficients with reported logP values of -2.8, -2.11, -2.01, -1.64, and -1.09, indicating a general trend towards hydrophilicity. In terms of bioactivity, Urea has been shown to inhibit Tyrosyl-DNA Phosphodiesterase (TDP1), Aldehyde Dehydrogenase 1 (ALDH1A1), Anthrax Lethal Toxin Internalization, peroxisome proliferator-activated receptor delta signaling, HP1-beta Chromodomain Interactions, Polymerase Iota, and the antioxidant response element (ARE) signaling pathway, with varying potencies. It also demonstrates diuretic activity in rats, leading to increased excretion of Cl-, K+, and Na+ ions. Additionally, Urea exhibits antiviral activity against SARS-CoV-2, though with moderate potency, affecting both cytotoxicity in VERO-6 cells and SARS-CoV-2 3CL-Pro protease inhibition. Its permeability characteristics include a permeability coefficient in human skin of log Kp = -7.39 and a capillary permeability of 8.2E-7 cm/s in Rat brain, suggesting potential for crossing biological barriers. The compound also shows substrate inhibition of Helicobacter pylori urease and agonist activity at the PSGR/OR51E2 receptor. Urea interacts with various liposome models, indicating binding activity to POPC/GMI and POPC liposomes. It inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells, and has shown substrate inhibition of Helicobacter pylori urease. Despite its broad range of activities, its permeability across human jejunum is notable at 1.4 x 10^-4 cm/s, with an aqueous diffusivity of 15.5 x 10^-6 cm²/s at 37°C, demonstrating its ability to cross intestinal barriers..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Urea (Carbonyldiamide) is formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end metabolite of protein catabolism and accounts for about one-half of the total urinary solids.
Synonyms	Ureophil, E-Cardamoni, Carbonyldiamide, Carbamide

Chemical Properties

Molecular Weight	60.06
Formula	CH₄N₂O
Cas No.	57-13-6
Smiles	C(N)(N)=O
Relative Density.	1.33 g/cm3. Temperature:20 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (4162.5 mM), Sonication is recommended.

H2O: 199.8 mM, Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (33.3 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	16.6500 mL	83.2501 mL	166.5002 mL	832.5008 mL
5 mM	3.3300 mL	16.6500 mL	33.3000 mL	166.5002 mL
10 mM	1.6650 mL	8.3250 mL	16.6500 mL	83.2501 mL
20 mM	0.8325 mL	4.1625 mL	8.3250 mL	41.6250 mL
50 mM	0.3330 mL	1.6650 mL	3.3300 mL	16.6500 mL
100 mM	0.1665 mL	0.8325 mL	1.6650 mL	8.3250 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc