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Sofituzumab vedotin (Synonyms: DMUC5754A)
Catalog No. T81133 Copy Product Info
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Sofituzumab vedotin is an anti-MUC16 antibody-drug conjugate (ADC) containing MMAE and a protease-cleavable linker, which can be used in cancer research.
Sofituzumab vedotin
Copy Product Info🥰Excellent
Catalog No. T81133
Synonyms DMUC5754A
Sofituzumab vedotin is an anti-MUC16 antibody-drug conjugate (ADC) containing MMAE and a protease-cleavable linker, which can be used in cancer research.
Sofituzumab vedotin
Cas No. 1418200-58-4
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $758 | 2-4 weeks | 2-4 weeks | |
| 5 mg | $1,880 | 2-4 weeks | 2-4 weeks | |
| 10 mg | Preferential | 2-4 weeks | 2-4 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Sofituzumab vedotin is an anti-MUC16 antibody-drug conjugate (ADC) containing MMAE and a protease-cleavable linker, which can be used in cancer research. |
| In vitro | Sofituzumab vedotin is an antibody-drug conjugate (ADC) consisting of a humanized IgG1 anti-MUC16 monoclonal antibody linked to the potent anti-mitotic agent MMAE via a protease-cleavable linker: maleimidocaproyl‑valine‑citrulline‑p‑aminobenzyloxycarbonyl [2]. Sofituzumab vedotin inhibits the proliferation of OVCAR‑3 and PC3/MUC16TMlong cells in a dose-dependent manner at concentrations ranging from 0.1 to 10000 ng/mL [3]. |
| In vivo | Sofituzumab vedotin administered intravenously (2, 2.8 mg/kg, once weekly for 3–4 doses) exerts significant antitumor effects against MUC16‑positive OVCAR‑3 xenograft tumors [3]. |
| Synonyms | DMUC5754A |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal, ADC |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | MMAE |
| Gene ID | |
| Uniprot ID | |
| Target | CA125/MUC16 |
| Cas No. | 1418200-58-4 |
| Isotype | IgG1 |
| Storage | Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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