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IPSU

Name: IPSU
Brand: TargetMol
SKU: T5503
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T5503 Copy Product Info

Purity: 97.05%

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IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors.

IPSU

Copy Product Info

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Catalog No. T5503

IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors.

Cas No. 1373765-19-5

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Pack Size	Price	USA Stock	Global Stock
2 mg	$47	In Stock	In Stock
5 mg	$78	In Stock	In Stock
10 mg	$98	In Stock	In Stock
25 mg	$211	In Stock	In Stock
50 mg	$315	In Stock	In Stock
100 mg	$455	In Stock	In Stock
200 mg	$697	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$84	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:97.05%

Appearance:Solid

Color:White

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COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors.
Targets&IC50	OX2:7.85 (pKi) , OX1:6.29 (pKi)
In vitro	BBAC or the selective OX2R antagonist IPSU bind rapidly and reach equilibrium very quickly in binding and/or functional assays[1].
In vivo	IPSU?exhibits an acceptable absolute oral bioavailability and a brain/blood concentration ratio that indicated favorable brain penetration.?IPSU increases sleep when dosed during the mouse active phase (lights off);?IPSU induces sleep primarily by increasing NREM sleep.?IPSU shows a fast onset of action, with a clear increase in total sleep time during the first hour afterdosing.?The effect lasts 4-5 h, after which time the total sleep time per hour is the same as on vehicle day[2]

Chemical Properties

Molecular Weight	405.49
Formula	C₂₃H₂₇N₅O₂
Cas No.	1373765-19-5
Smiles	COc1ccnc(n1)N1CCC2(CCCN(Cc3c[nH]c4ccccc34)C2=O)CC1
Relative Density.	1.32 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (73.98 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4662 mL	12.3308 mL	24.6615 mL	123.3076 mL
5 mM	0.4932 mL	2.4662 mL	4.9323 mL	24.6615 mL
10 mM	0.2466 mL	1.2331 mL	2.4662 mL	12.3308 mL
20 mM	0.1233 mL	0.6165 mL	1.2331 mL	6.1654 mL
50 mM	0.0493 mL	0.2466 mL	0.4932 mL	2.4662 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc