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Usmarapride free base

Name: Usmarapride free base
Brand: TargetMol
SKU: T34751
Price: 199 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T34751Cas No. 1428862-32-1

Alias SUVN-D4010 free base, SUVN-D-1208045 free base, SUVN-D1003019 free base, SUVN-D 4010 free base, SUVN-1004028 free base, SUVN D4010 free base

Usmarapride free base (SUVN-D4010 free base) is a selective and orally active 5-HT4 receptor partial agonist, increasing soluble amyloid precursor protein α levels, useful in Alzheimer's disease research.

Usmarapride free base

😃Good

Purity: 99.91%

Catalog No. T34751Alias SUVN-D4010 free base, SUVN-D-1208045 free base, SUVN-D1003019 free base, SUVN-D 4010 free base, SUVN-1004028 free base, SUVN D4010 free baseCas No. 1428862-32-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$199	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.91%

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COA

Product Introduction

Bioactivity

Description	Usmarapride free base (SUVN-D4010 free base) is a selective and orally active 5-HT4 receptor partial agonist, increasing soluble amyloid precursor protein α levels, useful in Alzheimer's disease research.
Targets&IC50	5-HT4 receptor:44 nM (EC50)
In vivo	Methods: Usmarapride free base (1 mg/kg, oral and 1 mg/kg, intravenous) was administered to male beagle dogs to evaluate the pharmacokinetics of Usmarapride free base. Results: Usmarapride free base was rapidly absorbed after oral administration (Tmax in the range of 0.5-0.75 hours), with oral exposure (AUC0-24h = 711 ± 369 ng·h/mL) and showed a long terminal venous half-life (6.0 ± 1.5 hours), moderate venous clearance (18 ± 6 mL/min/ kg) and volume of distribution (5.1 ± 0.6 L/kg), and an absolute oral bioavailability (%F) of 72 ± 11%.[1]
Synonyms	SUVN-D4010 free base, SUVN-D-1208045 free base, SUVN-D1003019 free base, SUVN-D 4010 free base, SUVN-1004028 free base, SUVN D4010 free base

Chemical Properties

Molecular Weight	383.49
Formula	C₂₁H₂₉N₅O₂
Cas No.	1428862-32-1
Smiles	N=1N=C(OC1C2=NN(C=3C=CC=CC23)C(C)C)C4CCN(CCCOC)CC4
Relative Density.	1.26 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (208.61 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6076 mL	13.0381 mL	26.0763 mL	130.3815 mL
5 mM	0.5215 mL	2.6076 mL	5.2153 mL	26.0763 mL
10 mM	0.2608 mL	1.3038 mL	2.6076 mL	13.0381 mL
20 mM	0.1304 mL	0.6519 mL	1.3038 mL	6.5191 mL
50 mM	0.0522 mL	0.2608 mL	0.5215 mL	2.6076 mL
100 mM	0.0261 mL	0.1304 mL	0.2608 mL	1.3038 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc