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TRPM8 antagonist 3

Name: TRPM8 antagonist 3
Brand: TargetMol
SKU: T9709
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T9709Cas No. 2102179-29-1

TRPM8 antagonist 3 is a blocker of TRPM8 (IC50 = 11 nM).

TRPM8 antagonist 3

🥰Excellent

Purity: 99.74%

Catalog No. T9709Cas No. 2102179-29-1

TRPM8 antagonist 3 is a blocker of TRPM8 (IC50 = 11 nM).

Pack Size	Price	Availability
1 mg	$34	In Stock
5 mg	$82	In Stock
10 mg	$128	In Stock
25 mg	$212	In Stock
50 mg	$309	In Stock
100 mg	$435	In Stock
1 mL x 10 mM (in DMSO)	$91	In Stock

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Batch Information

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Purity:99.74%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	TRPM8 antagonist 3 is a blocker of TRPM8 (IC50 = 11 nM).
Targets&IC50	TRPM8:11 nM

Chemical Properties

Molecular Weight	292.31
Formula	C₁₃H₁₂N₂O₄S
Cas No.	2102179-29-1
Smiles	Oc1nc(sc1C(=O)N1CCCO1)-c1ccccc1O
Relative Density.	1.517 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (171.05 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4210 mL	17.1051 mL	34.2103 mL	171.0513 mL
5 mM	0.6842 mL	3.4210 mL	6.8421 mL	34.2103 mL
10 mM	0.3421 mL	1.7105 mL	3.4210 mL	17.1051 mL
20 mM	0.1711 mL	0.8553 mL	1.7105 mL	8.5526 mL
50 mM	0.0684 mL	0.3421 mL	0.6842 mL	3.4210 mL
100 mM	0.0342 mL	0.1711 mL	0.3421 mL	1.7105 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc