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15(S)-Latanoprost

Name: 15(S)-Latanoprost
Brand: TargetMol
SKU: T37931
Rating: 4.5 (1 reviews)

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Catalog No. T37931Cas No. 145773-22-4

15(S)-Latanoprost is an analog of latanoprost in which the hydroxyl at carbon 15 is inverted relative to latanoprost. The IC50 values for the free acid forms of latanoprost and 15(S)-latanoprost were determined to be 3.6 nM and 24 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle. A 3 μg dose of 15(S)-latanoprost caused a 1 mmHg reduction of IOP in normotensive cynomolgus monkeys. 15(S)-Latanoprost is a potential impurity in most commercial preparations of the latanoprost bulk drug product.

15(S)-Latanoprost

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Catalog No. T37931Cas No. 145773-22-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$279	35 days	35 days
5 mg	$1,250	35 days	35 days
10 mg	$2,180	35 days	35 days
50 mg	$5,530	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	432.59
Formula	C₂₆H₄₀O₅
Cas No.	145773-22-4
Smiles	C(/C=C\CCCC(OC(C)C)=O)[C@@H]1[C@@H](CC[C@@H](CCC2=CC=CC=C2)O)[C@H](O)C[C@@H]1O
Relative Density.	1.093 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (231.17 mM), Sonication is recommended.

DMSO:PBS (1:12): 80 μg/mL, Sonication is recommended.

DMF: 100 mg/mL (231.17 mM), Sonication is recommended.

Ethanol: 100 mg/mL (231.17 mM), Sonication is recommended.

Solution Preparation Table

DMSO/DMF/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.3117 mL	11.5583 mL	23.1166 mL	115.5829 mL
5 mM	0.4623 mL	2.3117 mL	4.6233 mL	23.1166 mL
10 mM	0.2312 mL	1.1558 mL	2.3117 mL	11.5583 mL
20 mM	0.1156 mL	0.5779 mL	1.1558 mL	5.7791 mL
50 mM	0.0462 mL	0.2312 mL	0.4623 mL	2.3117 mL
100 mM	0.0231 mL	0.1156 mL	0.2312 mL	1.1558 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc