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Anti-ALK-4/ACVR1B Antibody (3Y53)
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Catalog No. TMAY-00990
Alias SKR2, ALK4, ACVRLK4, ACTRIB, activin A receptor, type IB
Anti-ALK-4/ACVR1B Antibody (3Y53) is a Mouse antibody targeting ALK-4/ACVR1B. Anti-ALK-4/ACVR1B Antibody (3Y53) can be used in ELISA.
Anti-ALK-4/ACVR1B Antibody (3Y53)
Anti-ALK-4/ACVR1B Antibody (3Y53)
😃Good
Catalog No. TMAY-00990Alias SKR2, ALK4, ACVRLK4, ACTRIB, activin A receptor, type IB
Anti-ALK-4/ACVR1B Antibody (3Y53) is a Mouse antibody targeting ALK-4/ACVR1B. Anti-ALK-4/ACVR1B Antibody (3Y53) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: ELISA Reactivity: Human |
| Alias | SKR2, ALK4, ACVRLK4, ACTRIB, activin A receptor, type IB |
| Ig Type | Mouse IgG1 |
| Clone | 3Y53 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ALK4 extracellular domain (rh ALK4; TMPY-01293; NP_004293.1; Met 1-Glu 126). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | ALK-4 (Activin Receptor-Like Kinase 4) or ACVR1B (Activin A Receptor, type 1B), belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, and TGFB receptor subfamily. ALK-4/ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. The known type II activin receptors include ActRII and ActRIIB, while the main type I activin receptor in mammalian cells is ALK-4 (ActRIB). In the presence of activin, type II and type I receptors form complexes whereby the type II receptors activate ALK-4 through phosphorylation. The activated ALK-4, in turn, transduces signals downstream by phosphorylation of its effectors, such as Smads, to regulate gene expression and affect cellular phenotype. ALK-4/ACVR1B is an important regulator of vertebrate development, with roles in mesoderm induction, primitive streak formation, gastrulation, dorsoanterior patterning, and left-right axis determination. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human ALK4 protein (TMPY-01293) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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