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ART0380
🥰Excellent
Catalog No. T85731Cas No. 2267316-76-5
Alias IACS-030380, IACS030380, ART 0380
ART0380 is a potent, selective, orally available, ATP-competitive ATR kinase inhibitor (IC50=51.7 nM) with antitumor activity for the study of ataxia telangiectasia mutated (ATM) cancer.
ART0380
🥰Excellent
Purity: 99.76%
Catalog No. T85731Alias IACS-030380, IACS030380, ART 0380Cas No. 2267316-76-5
ART0380 is a potent, selective, orally available, ATP-competitive ATR kinase inhibitor (IC50=51.7 nM) with antitumor activity for the study of ataxia telangiectasia mutated (ATM) cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $64 | In Stock | |
| 5 mg | $156 | In Stock | |
| 10 mg | $222 | In Stock | |
| 25 mg | $396 | In Stock | |
| 50 mg | $562 | In Stock | |
| 100 mg | $787 | In Stock | |
| 200 mg | $1,070 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $169 | In Stock |
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Purity:99.76%
ee:100%
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Product Introduction
Bioactivity
Chemical Properties
| Description | ART0380 is a potent, selective, orally available, ATP-competitive ATR kinase inhibitor (IC50=51.7 nM) with antitumor activity for the study of ataxia telangiectasia mutated (ATM) cancer. |
| In vivo | ART0380 is a potent and selective ATR inhibitor with a compelling in vitro and in vivo pharmacological profile and is currently in Phase 2 clinical studies in patients with advanced or metastatic solid tumors as monotherapy and in combination with DNA damaging agents (NCT04657068 and NCT05798611). ART0380 has a favorable human PK profile suitable for both intermittent and continuous once-daily (QD) dosing, characterized by dose-proportional increases in exposure and low variability. [2] |
| Synonyms | IACS-030380, IACS030380, ART 0380 |
| Molecular Weight | 388.49 |
| Formula | C18H24N6O2S |
| Cas No. | 2267316-76-5 |
| Smiles | C[C@H]1N(CCOC1)C2=NC(C3=CC=NC(N)=C3)=NC(N=S(C4CC4)(C)=O)=C2 |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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