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Piperine

Catalog No. T3002 CAS 94-62-2

Synonyms: 1-Piperoylpiperidine, Bioperine

Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.

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Piperine, CAS 94-62-2

Pack Size	Availability	Price/USD	Quantity
100 mg	In stock	$ 29.00
1 mL * 10 mM (in DMSO)	In stock	$ 30.00

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Purity: 100%

Purity: 97.79%

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Chemical Properties

Storage & Solubility Information

Description	Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.
Targets&IC50	P-gp:61.94±0.054 μg/mL, CYP3A4:61.94±0.054 μg/mL
In vitro	Piperine demonstrates varying lethality (LD50) across different routes of administration in animals. In mice, the LD50 values are 15.1 mg/kg for intravenous injection, 43 mg/kg for intraperitoneal injection, 200 mg/kg for subcutaneous injection, and 330 mg/kg for oral administration (gavage). In rats, the LD50 is 33.5 mg/kg for intraperitoneal injection and 514 mg/kg for oral administration (gavage).
In vivo	Magnolol exhibits antifungal activity, effectively inhibiting the growth of Trichophyton mentagrophytes, Microsporum gypsum, Epidermophyton floccosum, Aspergillus niger, Cryptococcus, and Candida albicans with a minimal inhibitory concentration (MIC) ranging from 25 to 100 μg/ml. In vitro, magnolol enhances the binding of [3H]-muscimol to the hippocampus.
Cell Research	Standard solution is prepared by dissolving 10 mg of piperine in 100 mL of methanol. The MTT assay is carried out to measure cell viability. Ten thousand cells in 100 μL of DMEM media are seeded in the wells of a 96-well plate. After 24 h, existing media is removed and 100 μL of various concentrations of piperine (20–100 μg/mL) are added and incubated for 48 h at 37 °C in a CO2 incubator. Control cells are supplemented with 0.05 % DMSO vehicle. At the 48th hour of incubation, MTT (10 μL of 5 mg/mL) is added to the plate. The contents of the plate are pipetted out carefully, the formazan crystals formed are dissolved in 100 μL of DMSO, and the absorbance is measured at 550 nm in a microplate reader[1].

Synonyms	1-Piperoylpiperidine, Bioperine
Molecular Weight	285.34
Formula	C17H19NO3
CAS No.	94-62-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 57 mg/mL (199.76 mM)

DMSO: 57 mg/mL (199.76 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Bhardwaj RK, et al. J Pharmacol Exp Ther, 2002, 302(2), 645-650. 2. Sunila ES, et al. J Ethnopharmacol, 2004, 90(2-3), 339-346. 3. Piyachaturawat P, et al. Toxicol Lett, 1983, 16(3-4), 351-359. 6. Zhai WJ, et al. Piperine Plays an Anti-Inflammatory Role in Staphylococcus aureus Endometritis by Inhibiting Activation of NF-κB and MAPK Pathways in Mice. Evid Based Complement Alternat Med. 2016;2016:8597208.

Citations

1. Gu D R, Yang H, Kim S C, et al. Water Extract of Piper longum Linn Ameliorates Ovariectomy-Induced Bone Loss by Inhibiting Osteoclast Differentiation. Nutrients. 2022, 14(17): 3667. 2. Gao R, Liu Z, Meng M, et al.Neurogenesis-Associated Protein, a Potential Prognostic Biomarker in Anti-PD-1 Based Kidney Renal Clear Cell Carcinoma Patient Therapeutics.Pharmaceuticals.2024, 17(4): 451.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Antiparasitic Natural Product Library Traditional Chinese Medicine Monomer Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Anti-Tumor Natural Product Library Anti-infective Natural Product Library Bioactive Compound Library

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Keywords

Piperine 94-62-2 Autophagy Membrane transporter/Ion channel Metabolism Neuroscience P450 Endogenous Metabolite P-gp Cluster of differentiation 243 Inhibitor Multidrug resistance protein 1 CD243 ABCB1 1-Piperoylpiperidine P-glycoprotein inhibit Pgp MDR1 Bioperine inhibitor

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