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Anti-CASP9 Antibody (3L280)
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Catalog No. TMAH-00145
Alias MCH6, ICE-like apoptotic protease 6, ICE-LAP6, EC 3.4.22.62, Caspase-9, Caspase9, CASP-9, Apoptotic protease-activating factor 3, Apoptotic protease Mch-6, APAF-3
Anti-CASP9 Antibody (3L280) is an antibody targeting CASP9. Anti-CASP9 Antibody (3L280) can be used in ELISA, IF, FC.
Anti-CASP9 Antibody (3L280)
Anti-CASP9 Antibody (3L280)
😃Good
Catalog No. TMAH-00145Alias MCH6, ICE-like apoptotic protease 6, ICE-LAP6, EC 3.4.22.62, Caspase-9, Caspase9, CASP-9, Apoptotic protease-activating factor 3, Apoptotic protease Mch-6, APAF-3
Anti-CASP9 Antibody (3L280) is an antibody targeting CASP9. Anti-CASP9 Antibody (3L280) can be used in ELISA, IF, FC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $208 | 7-10 days | |
| 100 μL | $348 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-CASP9 Antibody (3L280) is an antibody targeting CASP9. Anti-CASP9 Antibody (3L280) can be used in ELISA, IF, FC. |
| Alias | MCH6, ICE-like apoptotic protease 6, ICE-LAP6, EC 3.4.22.62, Caspase-9, Caspase9, CASP-9, Apoptotic protease-activating factor 3, Apoptotic protease Mch-6, APAF-3 |
| Ig Type | Rabbit IgG |
| Clone | 3L280 |
| Reactivity | Human |
| Verified Activity | 1. Immunofluorescence staining of HepG2 with TMAH-00145 at 1:7, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 525-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). 2. Overlay Peak curve showing HepG2 cells stained with TMAH-00145 (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1µg/1*10^6 cells) for 45min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4°C.Control antibody (green line) was rabbit IgG (1µg/1*10^6 cells) used under the same conditions. Acquisition of >10,000 events was performed. |
| Application | ELISA, IF, FC |
| Recommended Dose | IF:1:50-1:200; FC:1:50-1:200. |
| Antibody Type | Monoclonal |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human CASP9 |
| Antigen Species | Human |
| Gene ID | 842 |
| Uniprot ID | |
| Biology Area | Cancer, Cell biology, Metabolism |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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