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JH-LPH-33
🥰Excellent
Catalog No. T11716Cas No. 2414590-04-6
JH-LPH-33 is a UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor with antimicrobial activity for the study of bacterial infections.
JH-LPH-33
🥰Excellent
Purity: 98.29%
Catalog No. T11716Cas No. 2414590-04-6
JH-LPH-33 is a UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor with antimicrobial activity for the study of bacterial infections.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $149 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.29%
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Product Introduction
Bioactivity
Chemical Properties
| Description | JH-LPH-33 is a UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor with antimicrobial activity for the study of bacterial infections. |
| Targets&IC50 | LpxH (Klebsiella pneumoniae):0.026 μM |
| In vitro | The activity of JH-LPH-33 against Klebsiella pneumoniae LpxH and Escherichia coli LpxH exhibited IC50 values of 0.026 μM and 0.046 μM, respectively. JH-LPH-33 significantly inhibited bacterial growth at a concentration of 1.6 μg/mL, but its minimum inhibitory concentration (MIC) against E. coli exceeded 64 μg/mL. [1] |
| Molecular Weight | 487.92 |
| Formula | C21H21ClF3N3O3S |
| Cas No. | 2414590-04-6 |
| Smiles | O=C(N1C2=CC=C(C=C2CC1)S(=O)(=O)N3CCN(C4=CC(Cl)=CC(=C4)C(F)(F)F)CC3)C |
| Relative Density. | 1.448 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | DMSO: 1 mg/mL (2.05 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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