Ebastine (Kestine) (trade names Evastin, Kestine, Ebastel, Aleva) is a non-sedating H1 antihistamine. It does not penetrate the blood-brain barrier and thus allows an effective block of the H1 receptor in peripheral tissue without a central side effect, i. e not causing sedation or drowsiness.

Compared to H2 receptors, Ebastine showed selectivity for histamine H1, moderate activity against other potential mediators of allergic phenomena such as leukotriene C4 and platelet-activating factor, and was apparently effective in targeting allergic reaction antigens induced by exposure of appropriately sensitized tissues or animals to allergies.Ebastine inhibited, in human nasal polyp cells, anti-IgE-induced prostaglandin D2 and leukotriene C4/D4 with IC30 of 2.57 μM and 9.6 μM, respectively, and inhibited cytokine release.Ebastine also inhibited hERG-expressing IKr in African Xenopus oocytes with a Kd value of 0.3 μM, with a maximal inhibition of 46% at 3 μM.Ebastine exerted a small effect on transient potassium currents in rats at a concentration of less than 100 nM. Ebastine had a small effect on the transient potassium current in rats at concentrations less than 100 nM.

DMSO: 4.7 mg/mL (10.01 mM), Sonication is recommended.