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Ketorolac
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Catalog No. T21412Cas No. 74103-06-3
Alias Toradol, Sprix, Macril, Acuvail, Acular
Ketorolac (Acuvail) is a non-steroidal anti-inflammatory drug (NSAID) in the family of heterocyclic acetic acid derivatives. It acts by inhibiting the bodily synthesis of prostaglandins.
Ketorolac
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Purity: 99.68%
Catalog No. T21412Alias Toradol, Sprix, Macril, Acuvail, AcularCas No. 74103-06-3
Ketorolac (Acuvail) is a non-steroidal anti-inflammatory drug (NSAID) in the family of heterocyclic acetic acid derivatives. It acts by inhibiting the bodily synthesis of prostaglandins.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 100 mg | $35 | In Stock | In Stock | |
| 500 mg | $80 | In Stock | In Stock | |
| 1 g | $117 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.68%
Appearance:Solid
Color:White
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Product Introduction
Ketorolac AI Summary
Ketorolac demonstrates a wide array of bioactivities including significant anti-inflammatory and analgesic effects at various dosages. Specifically, it inhibits carrageenan-induced edema in rats at 15 mg/kg, phenylquinone-induced writhing in mice at 70 mg/kg, cotton pellet granuloma in mice at 0.5 mg/kg, and adjuvant-induced arthritis in rats at 2.0 mg/kg. However, it also induces chronic gastrointestinal erosive activity in rats at 5.0 mg/kg. The therapeutic ratio of gastrointestinal erosion to anti-inflammatory activity in rat paw is 18.0, suggesting a favorable balance.
Pharmacokinetic studies show that Ketorolac has high oral bioavailability (≥80%), rapid absorption with a Tmax of 1 hour, and moderate systemic clearance. It exhibits high plasma protein binding (99.2%) and moderate lipophilicity (LogP ~2.7). Specific enzyme inhibition includes COX-1 with an IC50 of 13.0 nM, COX-2 with an IC50 of 424.0 nM, and prostaglandin synthetase activity in mouse brain microsomes with an IC50 of 230.0 nM. Ketorolac also demonstrates properties such as a moderate pKa of 3.49, acceptable chemical stability, and diverse bioactivities including potential antiviral and antihyperalgesic effects.
Despite its therapeutic potential, Ketorolac shows moderate risk for liver toxicity and gastrointestinal side effects, with an ulcerogenic effect comparable to ketorolac and a notable liver toxicity severity score. Overall, Ketorolac is a potent anti-inflammatory and analgesic agent with a complex pharmacological profile, necessitating careful consideration of its side effects in therapeutic applications..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Ketorolac (Acuvail) is a non-steroidal anti-inflammatory drug (NSAID) in the family of heterocyclic acetic acid derivatives. It acts by inhibiting the bodily synthesis of prostaglandins. |
| Targets&IC50 | COX-2:120 nM , COX-1:20 nM |
| Synonyms | Toradol, Sprix, Macril, Acuvail, Acular |
| Molecular Weight | 255.27 |
| Formula | C15H13NO3 |
| Cas No. | 74103-06-3 |
| Smiles | OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 |
| Relative Density. | 1.398 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (176.28 mM), Sonication is recommended.  H2O: 70 mg/mL (274.22 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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