Anti-PKM2 Polyclonal Antibody

Name: Anti-PKM2 Polyclonal Antibody
Brand: TargetMol
SKU: TMAB-01544
Rating: 4.5 (1 reviews)

(Synonyms: THBP1, TCB, pyruvate kinase, muscle, PKM2, PK3, OIP3, HEL-S-30, CTHBP) Copy Product Info

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Synonyms: THBP1, TCB, pyruvate kinase, muscle, PKM2, PK3, OIP3, HEL-S-30, CTHBP

Catalog No. TMAB-01544 Copy Product Info

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Anti-PKM2 Polyclonal Antibody is a Mouse antibody targeting PKM2. Anti-PKM2 Polyclonal Antibody can be used in ICC/IF, IF, IHC-Fr, IHC-P, WB.

Anti-PKM2 Polyclonal Antibody

Pack Size	Price	USA Stock	Global Stock
50 μL	$221	7-10 days	7-10 days
100 μL	$374	7-10 days	7-10 days
200 μL	$527	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Instruction Manual of Detection Antibody

Product Introduction

Bioactivity

Description	Anti-PKM2 Polyclonal Antibody is a Mouse antibody targeting PKM2. Anti-PKM2 Polyclonal Antibody can be used in ICC/IF, IF, IHC-Fr, IHC-P, WB.
Synonyms	THBP1, TCB, pyruvate kinase, muscle, PKM2, PK3, OIP3, HEL-S-30, CTHBP
Ig Type	IgG
Reactivity	Human,Mouse,Rat (predicted:Pig,Cow,Horse,Rabbit)

Application	ICC/IF IF IHC-Fr IHC-P WB
Recommended Dose	ICC/IF=1:100-500; IF=1:100-500; IHC-Fr=1:100-500; IHC-P=1:100-500; WB=1:500-2000
Antibody Type	Polyclonal
Host Species	Mouse
Subcellular Localization	Cytoplasm. Nucleus. Note=Translocates to the nucleus in response to different apoptotic stimuli. Nuclear translocation is sufficient to induce cell death that is caspase independent, isoform-specific and independent of its enzymatic activity.
Tissue Specificity	Specifically expressed in proliferating cells, such as embryonic stem cells, embryonic carcinoma cells, as well as cancer cells.
Construction	Polyclonal Antibody
Purification	Protein A purified
Appearance	Liquid
Formulation	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration	1 mg/mL
Research Background	The protein encoded by this gene is a pyruvate kinase that catalyzes the production of phosphoenolpyruvate from pyruvate and ATP. This protein has been shown to interact with thyroid hormone, and thus may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.

Antigen Details

Immunogen	KLH conjugated synthetic peptide: human PKM2
Antigen Species	Human
Gene Name	PKM
Gene ID	5315
Protein Name	Pyruvate kinase PKM
Uniprot ID	P14618
Biology Area	Energy Metabolism,Energy Metabolism,Carbohydrate metabolism,Kinases/Phosphatases,Enzymes,Metabolism of carbohydrates
Function	Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.