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RH1
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Catalog No. T16740Cas No. 221635-42-3
Alias NSC 697726
RH1 (NSC 697726) is a bioreductive anticancer compound that exhibits dose-dependent biphasic effects in vitro, inducing apoptosis at higher doses and senescence at lower doses.
RH1
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Purity: 99.15%
Catalog No. T16740Alias NSC 697726Cas No. 221635-42-3
RH1 (NSC 697726) is a bioreductive anticancer compound that exhibits dose-dependent biphasic effects in vitro, inducing apoptosis at higher doses and senescence at lower doses.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $197 | - | In Stock | |
| 5 mg | $446 | In Stock | In Stock | |
| 10 mg | $718 | - | In Stock | |
| 25 mg | $1,450 | - | In Stock | |
| 50 mg | $1,980 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.15%
Appearance:Solid
Color:Red
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | RH1 (NSC 697726) is a bioreductive anticancer compound that exhibits dose-dependent biphasic effects in vitro, inducing apoptosis at higher doses and senescence at lower doses. |
| In vitro | RH1 causes apoptosis in NQ16 cells in a time- and concentration-dependent manner. Treatment of NQ16 cells with RH1 (50 and 100 nM) for 60 and 120 minutes resulted in a significant (p< 0.05) increase in cross-linked DNA [1]. |
| In vivo | RH1 exhibited dose-dependent antitumor activity against NQ16 tumors grown in thymus-free mice. A small dose of RH1 (0.1 mg/kg) also resulted in a significant reduction in tumor size in treated mice compared to controls. Treatment of mice with NQ16 tumors with RH1 (0.4 mg/kg and 0.2 mg/kg) resulted in a significant reduction in tumor size between the treated and control groups as early as 5 days after the end of the treatment period [2]. |
| Synonyms | NSC 697726 |
| Molecular Weight | 234.25 |
| Formula | C12H14N2O3 |
| Cas No. | 221635-42-3 |
| Smiles | O=C1C(=C(C(=O)C(=C1C)N2CC2)CO)N3CC3 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | DMSO: 1 mg/mL (4.27 mM), Sonication and heating are recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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