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Acivicin hydrochloride

Name: Acivicin hydrochloride
Brand: TargetMol
SKU: T77207
Price: 149 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T77207Cas No. 161922-40-3

Alias U-42126 hydrochloride, U42126 hydrochloride, AT-125 hydrochloride, AT125 hydrochloride

Acivicin hydrochloride is the hydrochloride form of Acivicin (AT125, U42126).Acivicin, a natural product from Streptomyces sviceus (Streptomyces), is a glutamine analog and a potent inhibitor of γ-glutamyltransferase (GGT) and a potent inhibitor of l -Asparagine synthetase and other l-glutamine aminotransferases, and is cytotoxic by blocking nucleotide biosynthesis.

Acivicin hydrochloride

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Purity: 99.14%

Catalog No. T77207Alias U-42126 hydrochloride, U42126 hydrochloride, AT-125 hydrochloride, AT125 hydrochlorideCas No. 161922-40-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$149	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.14%

Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Acivicin hydrochloride is the hydrochloride form of Acivicin (AT125, U42126).Acivicin, a natural product from Streptomyces sviceus (Streptomyces), is a glutamine analog and a potent inhibitor of γ-glutamyltransferase (GGT) and a potent inhibitor of l -Asparagine synthetase and other l-glutamine aminotransferases, and is cytotoxic by blocking nucleotide biosynthesis.
In vitro	Methods: HepG2 cells were treated with Acivicin hydrochloride (0.1-50 μM, 5 days) and cell viability was measured. Results: Its IC50 value in HepG2 cells was 0.7 μM. [1]
Synonyms	U-42126 hydrochloride, U42126 hydrochloride, AT-125 hydrochloride, AT125 hydrochloride

Chemical Properties

Molecular Weight	215.04
Formula	C₅H₈Cl₂N₂O₃
Cas No.	161922-40-3
Smiles	[C@H](C(O)=O)(N)[C@]1(ON=C(Cl)C1)[H].Cl

Storage & Solubility Information

Storage

store under nitrogen | store at 4°C | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (372.02 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (15.35 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.6503 mL	23.2515 mL	46.5030 mL	232.5149 mL
5 mM	0.9301 mL	4.6503 mL	9.3006 mL	46.5030 mL
10 mM	0.4650 mL	2.3251 mL	4.6503 mL	23.2515 mL
20 mM	0.2325 mL	1.1626 mL	2.3251 mL	11.6257 mL
50 mM	0.0930 mL	0.4650 mL	0.9301 mL	4.6503 mL
100 mM	0.0465 mL	0.2325 mL	0.4650 mL	2.3251 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc