Shopping Cart
- Remove All
Your shopping cart is currently empty
Anti-BMPR1A/ALK-3 Antibody (6X147)
🥰Excellent
Catalog No. TMAY-03081
Anti-BMPR1A/ALK-3 Antibody (6X147) is a Rabbit antibody targeting BMPR1A/ALK-3. Anti-BMPR1A/ALK-3 Antibody (6X147) can be used in ELISA.
Anti-BMPR1A/ALK-3 Antibody (6X147)
Anti-BMPR1A/ALK-3 Antibody (6X147)
🥰Excellent
Catalog No. TMAY-03081
Anti-BMPR1A/ALK-3 Antibody (6X147) is a Rabbit antibody targeting BMPR1A/ALK-3. Anti-BMPR1A/ALK-3 Antibody (6X147) can be used in ELISA.
Product information is being updated, if you want to purchase, please click the bulk custom button.
Bulk & Custom
Questions
View MoreContact us for more batch information
Resource Download
Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-BMPR1A/ALK-3 Antibody (6X147) is a Rabbit antibody targeting BMPR1A/ALK-3. Anti-BMPR1A/ALK-3 Antibody (6X147) can be used in ELISA. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 6X147 |
| Reactivity | Mouse |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse ALK-3 / BMPRIA (rM ALK-3 / BMPRIA; TMPY-01374; NP_033888.2; Met 1-Arg 152). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Activin receptor-Like Kinase 3 (ALK-3), also known as Bone Morphogenetic Protein Receptor, type IA (BMPR1A), is a type I receptor for bone morphogenetic proteins (BMPs) which belong to the transforming growth factor beta (TGF-β) superfamily. The BMP receptors form a subfamily of transmembrane serine/threonine kinases including the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. ALK-3/BMPR1A is expressed in the epithelium during branching morphogenesis. Deletion of BMPR1A in the epithelium with an Sftpc-cre transgene leads to dramatic defects in lung development. ALK-3 and ALK-6 share a high degree of homology, yet possess distinct signaling roles. The transforming growth factor (TGF)-beta type III receptor (TbetaRIII) enhanced both ALK-3 and ALK-6 signaling. TbetaRIII associated with ALK-3 primarily through their extracellular domains, whereas its interaction with ALK-6 required both the extracellular and cytoplasmic domains. ALK-3 plays an essential role in the formation of embryonic ventral abdominal wall, and abrogation of BMP signaling activity due to gene mutations in its signaling components could be one of the underlying causes of omphalocele at birth. The type IA BMP receptor, ALK-3 was specifically required at mid-gestation for normal development of the trabeculae, compact myocardium, interventricular septum, and endocardial cushion. Cardiac muscle lacking ALK-3 was specifically deficient in expressing TGFbeta2, an established paracrine mediator of cushion morphogenesis. Hence, ALK-3 is essential, beyond just the egg cylinder stage, for myocyte-dependent functions and signals in cardiac organogenesis. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Mouse ALK-3 / BMPRIA protein (TMPY-01374) |
| Antigen Species | Mouse |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
Sci Citations
Calculator
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Anti-BMPR1A/ALK-3 Antibody (6X147) | purchase Anti-BMPR1A/ALK-3 Antibody (6X147) | Anti-BMPR1A/ALK-3 Antibody (6X147) cost | order Anti-BMPR1A/ALK-3 Antibody (6X147)
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.