Anti-EIF2AK3/PERK Antibody (1P242) is a Mouse antibody targeting EIF2AK3/PERK. Anti-EIF2AK3/PERK Antibody (1P242) can be used in WB,ELISA.

IgG1

1P242

Mouse,Rat (predicted:Human)

25 ug total protein per lane of various lysates (see on figure) probed with EIF2AK3/PERK monoclonal antibody, unconjugated (TMAB-05489) at 1: 1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r. T. for 60 min.

WB: 1:500-2000; ELISA: 1:5000-10000

Monoclonal

Recombinant Protein: human EIF2AK3

Human

EIF2AK3

Eukaryotic translation initiation factor 2-alpha kinase 3

Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions (PubMed:9930704, PubMed:11106749, PubMed:23921556).Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as unfolded protein response (UPR) and low amino acid availability (PubMed:9930704, PubMed:11106749, PubMed:23921556).EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:11106749, PubMed:23921556).Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (PubMed:11035797).Involved in control of mitochondrial morphology and function (PubMed:23921556).