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Anti-EIF2AK3/PERK Antibody (1P242)
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Catalog No. TMAB-05489
Anti-EIF2AK3/PERK Antibody (1P242) is a Mouse antibody targeting EIF2AK3/PERK. Anti-EIF2AK3/PERK Antibody (1P242) can be used in WB,ELISA.
Anti-EIF2AK3/PERK Antibody (1P242)
Anti-EIF2AK3/PERK Antibody (1P242)
😃Good
Catalog No. TMAB-05489
Anti-EIF2AK3/PERK Antibody (1P242) is a Mouse antibody targeting EIF2AK3/PERK. Anti-EIF2AK3/PERK Antibody (1P242) can be used in WB,ELISA.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $298 | 7-10 days | 7-10 days | |
| 100 μL | $472 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-EIF2AK3/PERK Antibody (1P242) is a Mouse antibody targeting EIF2AK3/PERK. Anti-EIF2AK3/PERK Antibody (1P242) can be used in WB,ELISA. |
| Ig Type | IgG1 |
| Clone | 1P242 |
| Reactivity | Mouse,Rat (predicted:Human) |
| Application | |
| Recommended Dose | WB: 1:500-2000; ELISA: 1:5000-10000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | Endoplasmic reticulum membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Ubiquitous. |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein G purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Jan 2010]. |
| Immunogen | Recombinant Protein: human EIF2AK3 |
| Antigen Species | Human |
| Gene Name | EIF2AK3 |
| Gene ID | |
| Protein Name | Eukaryotic translation initiation factor 2-alpha kinase 3 |
| Uniprot ID | |
| Function | Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions (PubMed:9930704, PubMed:11106749, PubMed:23921556).Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as unfolded protein response (UPR) and low amino acid availability (PubMed:9930704, PubMed:11106749, PubMed:23921556).EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:11106749, PubMed:23921556).Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (PubMed:11035797).Involved in control of mitochondrial morphology and function (PubMed:23921556). |
| Molecular Weight | Theoretical: 122 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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