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Lanatoside C

Name: Lanatoside C
Brand: TargetMol
SKU: T1670
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1670Cas No. 17575-22-3

Alias Isolanid, Ceglunate, Cedilanid

Lanatoside C (Ceglunate) is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). Lanatoside C can be used orally or by the intravenous route.

Lanatoside C

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Purity: 99.99%

Catalog No. T1670Alias Isolanid, Ceglunate, CedilanidCas No. 17575-22-3

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	In Stock	In Stock
10 mg	$48	In Stock	In Stock
25 mg	$75	In Stock	In Stock
50 mg	$113	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.99%

Color:White

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COA HNMR LCMS

Product Introduction

Lanatoside C AI Summary

Lanatoside C demonstrates a broad range of biological activities. It shows binding affinities for various human monoclonal antibodies with IC50 ratios ranging from 1.1 to 1.6, and additionally binds to mouse monoclonal antibody DIG 64.2B.5 with an IC50 ratio of 1.2 in ELISA relative to digoxin. The compound exhibits cytotoxicity in human cancer cell lines including CC20, HCT116, and HT-29 with survival percentages of 2.0%, 5.0%, and 40.0%, respectively, at a concentration of 10 µM over 72 hours (FMCA method). Bioactivity evaluations indicate that Lanatoside C inhibits interactions involving the thyroid hormone receptor, ROR gamma transcriptional activity, Nrf2, VEEV, and TGF-b. It also inhibits cell growth in diverse human tumor cell lines (breast, renal, lung, prostate, melanoma, leukemia, and CNS), induces DNA re-replication in certain cells, and shows cytotoxicity against various cancer cell lines and viruses. In transporter assays, Lanatoside C inhibits sodium fluorescein uptake in OATP1B1-transfected and OATP1B3-transfected CHO cells by 102.51% and 86.15% respectively at 10 µM. It exhibits a selectivity index of 1.0 for antiviral versus cytotoxic activity in Vero cells, maintaining high cell viability (CC50 > 50,000 nM) while demonstrating antiviral activity against SARS-CoV-2 with an IC50 > 50,000 nM. The compound shows potent antiviral activity against Dengue virus strains (1-4) in human Huh7 cells with an IC50 value of 500.0 nM across all strains after 48 hours (plaque assay), and a specific IC50 of 190.0 nM against DENV2 over 72 hours (immunofluorescence). Despite extensive evaluations, no significant interaction or specific bioactivity below the AC50 threshold of 30,000 nM has been observed in the provided assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Lanatoside C (Ceglunate) is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). Lanatoside C can be used orally or by the intravenous route.
Targets&IC50	DENV (HuH-7 cells):0.19 μM
Synonyms	Isolanid, Ceglunate, Cedilanid

Chemical Properties

Molecular Weight	985.12
Formula	C₄₉H₇₆O₂₀
Cas No.	17575-22-3
Smiles	[H][C@]12CC[C@]3([H])[C@]([H])(C[C@@H](O)[C@]4(C)[C@H](CC[C@]34O)C3=CC(=O)OC3)[C@@]1(C)CC[C@@H](C2)O[C@H]1C[C@H](O)[C@H](O[C@H]2C[C@H](O)[C@H](O[C@H]3C[C@H](OC(C)=O)[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@H](C)O3)[C@@H](C)O2)[C@@H](C)O1
Relative Density.	1.42 g/cm3 at 20℃

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (50.76 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.03 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0151 mL	5.0755 mL	10.1510 mL	50.7552 mL
5 mM	0.2030 mL	1.0151 mL	2.0302 mL	10.1510 mL
10 mM	0.1015 mL	0.5076 mL	1.0151 mL	5.0755 mL
20 mM	0.0508 mL	0.2538 mL	0.5076 mL	2.5378 mL
50 mM	0.0203 mL	0.1015 mL	0.2030 mL	1.0151 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc