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3-Pyridinemethanol

Name: 3-Pyridinemethanol
Brand: TargetMol
SKU: T1299
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1299Cas No. 100-55-0

Alias Roniacol, Nicotinyl alcohol

3-Pyridinemethanol (Roniacol) is an alcohol analog of NICOTINIC ACID which is a direct-acting peripheral vasodilator that causes flushing and may decrease blood pressure. It is used in vasospasm and threatened GANGRENE.

3-Pyridinemethanol

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Purity: 99.30%

Catalog No. T1299Alias Roniacol, Nicotinyl alcoholCas No. 100-55-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.30%

Appearance:Liquid

Color:Transparent to Yellow

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COA HNMR LCMS

Product Introduction

3-Pyridinemethanol AI Summary

3-Pyridinemethanol exhibits a wide range of bioactivities including inhibitory effects against multiple targets. It acts as an inhibitor of GCN5L2, blocks the interaction between CBF-beta and RUNX1 for the treatment of acute myeloid leukemia, and inhibits binding or entry into cells for both Marburg Virus and Ebola Virus, with potency ranging from 2511.9 nM to 39810.7 nM in various assays. Additionally, 3-Pyridinemethanol is active against SARS-CoV-2, having shown moderate activity with a hit score of 0.2034 in HRCE cells and an IC50 value greater than 20000.0 nM in VERO-6 cells assays. The compound also exhibits hypoglycemic activity, reducing blood glucose levels in 48-hour fasted Charles River rats by 11.0% at 1 hour, -3.0% at 2 hours, and 19.0% at 4 hours after oral administration of 150 mg/kg. 3-Pyridinemethanol has shown mild to moderate activity against various bacteria and fungi, including moderate antibacterial effects against Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, and MRSA. Furthermore, it demonstrates inhibitory activity on human HDAC6, with 9.87% and 11.42% inhibition in enzymatic assays using commercial and custom peptide substrates, respectively..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	3-Pyridinemethanol (Roniacol) is an alcohol analog of NICOTINIC ACID which is a direct-acting peripheral vasodilator that causes flushing and may decrease blood pressure. It is used in vasospasm and threatened GANGRENE.
Synonyms	Roniacol, Nicotinyl alcohol

Chemical Properties

Molecular Weight	109.13
Formula	C₆H₇NO
Cas No.	100-55-0
Smiles	OCC1=CC=CN=C1
Relative Density.	1.124g/mLat 25°C(lit.)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (549.8 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (18.33 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	9.1634 mL	45.8169 mL	91.6338 mL	458.1692 mL
5 mM	1.8327 mL	9.1634 mL	18.3268 mL	91.6338 mL
10 mM	0.9163 mL	4.5817 mL	9.1634 mL	45.8169 mL
20 mM	0.4582 mL	2.2908 mL	4.5817 mL	22.9085 mL
50 mM	0.1833 mL	0.9163 mL	1.8327 mL	9.1634 mL
100 mM	0.0916 mL	0.4582 mL	0.9163 mL	4.5817 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc