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Progabide

Name: Progabide
Brand: TargetMol
SKU: T16581
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16581Cas No. 62666-20-0

Alias SL 76002, Halogabide, Gabrene, Gabren

Progabide (SL 76002) is an agonist of the gamma-aminobutyric acid receptor.

Progabide

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Purity: 99.68%

Catalog No. T16581Alias SL 76002, Halogabide, Gabrene, GabrenCas No. 62666-20-0

Progabide (SL 76002) is an agonist of the gamma-aminobutyric acid receptor.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$40	In Stock	In Stock
10 mg	$64	In Stock	In Stock
25 mg	$98	In Stock	In Stock
50 mg	$147	In Stock	In Stock
100 mg	$222	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.68%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Progabide (SL 76002) is an agonist of the gamma-aminobutyric acid receptor.
In vivo	Progabide ( 50, 100 and 200 mg/kg) given IP to male Wistar rats enhance the plasma corticosterone levels by 244, 365, and 476% respectively (t=6.44 to12.55, p<0.01). Progabide (10 mg/kg) fails to change the concentration of corticosterone in plasma (t=0.76, N.S.). The increased plasma corticosterone level induced by administration of 200 mg/kg Progabide is evident 30 (t=2.625, p<0.05), 60 (t=13.13, p<0.001) and 120 min (t=4.07, p<0.01) after drug injection, but returns to the control value 240 min after drug injection (t=0.86, N.S.). Compare with the corresponding control, The greatest corticosterone rise is reached 60 min following the administration of Progabide[1].
Synonyms	SL 76002, Halogabide, Gabrene, Gabren

Chemical Properties

Molecular Weight	334.77
Formula	C₁₇H₁₆ClFN₂O₂
Cas No.	62666-20-0
Smiles	NC(=O)CCC\N=C(\c1ccc(Cl)cc1)c1cc(F)ccc1O
Relative Density.	1.2822 g/cm3 (Estimated)

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (746.78 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9871 mL	14.9356 mL	29.8713 mL	149.3563 mL
5 mM	0.5974 mL	2.9871 mL	5.9743 mL	29.8713 mL
10 mM	0.2987 mL	1.4936 mL	2.9871 mL	14.9356 mL
20 mM	0.1494 mL	0.7468 mL	1.4936 mL	7.4678 mL
50 mM	0.0597 mL	0.2987 mL	0.5974 mL	2.9871 mL
100 mM	0.0299 mL	0.1494 mL	0.2987 mL	1.4936 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc