IL-1RAP/IL-1RAcP Protein, Mouse, Recombinant (aa 21-367, His)

Interleukin (IL)-1R3 is the co-receptor in three signaling pathways that involve six cytokines of the IL-1 family (IL-1α, IL-1β, IL-33, IL-36α, IL-36β and IL-36γ). In many diseases, multiple cytokines contribute to disease pathogenesis. For example, in asthma, both IL-33 and IL-1 are of major importance, as are IL-36 and IL-1 in psoriasis.

Pack Size	Availability	Price/USD
100 μg	5 days	$ 255.00
500 μg	5 days	$ 1,020.00
1 mg	5 days	$ 1,700.00

Pack Size

Availability

Price/USD

Quantity

100 μg

5 days

$ 255.00

500 μg

5 days

$ 1,020.00

1 mg

5 days

$ 1,700.00

Description

Species	Mouse
Expression System	HEK293
Tag	C-His
Accession Number	Q61730-1
Synonyms	C3orf13, IL1RAP, IL-1 R3, IL-1 RAcP
Construction	Recombinant Mouse IL-1R3/IL-1 RAcP Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Ser21-Thr367.[Accession \|Q61730-1]
Protein Purity	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Molecular Weight	The protein has a predicted MW of 41.1 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Tris-Bis PAGE result.

Endotoxin	Less than 1EU per μg by the LAL method.
Formulation	Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability & Storage	-20 to -80°C for 12 months as supplied from date of receipt. -20 to -80°C for 3-6 months in unopened state after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background	Interleukin (IL)-1R3 is the co-receptor in three signaling pathways that involve six cytokines of the IL-1 family (IL-1α, IL-1β, IL-33, IL-36α, IL-36β and IL-36γ). In many diseases, multiple cytokines contribute to disease pathogenesis. For example, in asthma, both IL-33 and IL-1 are of major importance, as are IL-36 and IL-1 in psoriasis.