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Inosine

Name: Inosine
Brand: TargetMol
SKU: T0437
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0437Cas No. 58-63-9

Alias NSC 20262, INO 495

Inosine (NSC-20262), an endogenous purine nucleoside produced by the catabolism of adenosine, is an agonist of adenosine receptors A1R and A2AR. Inosine has anti-inflammatory, immunomodulatory, antinociceptive and neuroprotective effects.

Inosine

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Purity: 99.89%

Catalog No. T0437Alias NSC 20262, INO 495Cas No. 58-63-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.89%

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Inosine (NSC-20262), an endogenous purine nucleoside produced by the catabolism of adenosine, is an agonist of adenosine receptors A1R and A2AR. Inosine has anti-inflammatory, immunomodulatory, antinociceptive and neuroprotective effects.
Targets&IC50	PvENT1:3.8 μM
In vitro	METHODS: Rat C6, DU-145, HaCaT, L6, and MCF7 cells were treated with Inosine (0-250 μM) for 48 hours, and MTT assay was used to detect the inhibition of cell growth. RESULTS: Inosine did not inhibit the growth of C6, DU-145, HaCaT, L6 and MCF7 cells at 250 μM. [1]
In vivo	METHODS: To study the analgesic effect of Inosine, Inosine (1 mg/kg, 10 mg/kg, and 100 mg/kg) was injected intraperitoneally to mice 20 min before formalin treatment. RESULTS: Inosine reduced formalin-induced leg withdrawal. [2]
Synonyms	NSC 20262, INO 495

Chemical Properties

Molecular Weight	268.23
Formula	C₁₀H₁₂N₄O₅
Cas No.	58-63-9
Smiles	O[C@H]1[C@H](N2C3=C(N=C2)C(=O)N=CN3)O[C@H](CO)[C@H]1O
Relative Density.	2.08 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 245 mg/mL (913.4 mM), Sonication is recommended.

H2O: 43 mg/mL (160.31 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (18.64 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7281 mL	18.6407 mL	37.2814 mL	186.4072 mL
5 mM	0.7456 mL	3.7281 mL	7.4563 mL	37.2814 mL
10 mM	0.3728 mL	1.8641 mL	3.7281 mL	18.6407 mL
20 mM	0.1864 mL	0.9320 mL	1.8641 mL	9.3204 mL
50 mM	0.0746 mL	0.3728 mL	0.7456 mL	3.7281 mL
100 mM	0.0373 mL	0.1864 mL	0.3728 mL	1.8641 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Inosine

Inosine

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In Vivo Formulation Calculator (Clear solution)

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