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CAXII-IN-3
Catalog No. T213012 Copy Product Info
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CAXII-IN-3 is a potent carbonic anhydrase (CA XII) inhibitor, with a Ki of 53 nM. It selectively inhibits various human CA isoforms, showing Ki values of 5.3 μM for CA I, 75 nM for CA II, 1.9 μM for CA IV, and > 10 μM for CA IX. Primarily targeting CA II and CA XII, CAXII-IN-3 reduces aqueous humor production. Additionally, it exhibits β3-AR agonist activity, leading to retinal blood vessel dilation and improved optic nerve perfusion. CAXII-IN-3 is applicable in the study of ocular diseases such as glaucoma.
CAXII-IN-3
Copy Product Info🥰Excellent
Catalog No. T213012
CAXII-IN-3 is a potent carbonic anhydrase (CA XII) inhibitor, with a Ki of 53 nM. It selectively inhibits various human CA isoforms, showing Ki values of 5.3 μM for CA I, 75 nM for CA II, 1.9 μM for CA IV, and > 10 μM for CA IX. Primarily targeting CA II and CA XII, CAXII-IN-3 reduces aqueous humor production. Additionally, it exhibits β3-AR agonist activity, leading to retinal blood vessel dilation and improved optic nerve perfusion. CAXII-IN-3 is applicable in the study of ocular diseases such as glaucoma.
CAXII-IN-3
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | CAXII-IN-3 is a potent carbonic anhydrase (CA XII) inhibitor, with a Ki of 53 nM. It selectively inhibits various human CA isoforms, showing Ki values of 5.3 μM for CA I, 75 nM for CA II, 1.9 μM for CA IV, and > 10 μM for CA IX. Primarily targeting CA II and CA XII, CAXII-IN-3 reduces aqueous humor production. Additionally, it exhibits β3-AR agonist activity, leading to retinal blood vessel dilation and improved optic nerve perfusion. CAXII-IN-3 is applicable in the study of ocular diseases such as glaucoma. |
| Targets&IC50 | CA XII (human):53 nM (Ki) |
| In vitro | CAXII-IN-3 (Compound 14) enhances cAMP production in HEK293T cells expressing stable β1, β2, and β3 adrenergic receptor subtypes, with pEC50 values of 5.00, 5.29, and 4.98, respectively. It also induces complete vasodilation in porcine retinal arteriolar rings with an EC50 of 11 μM. Additionally, at a concentration of 4 μM for 2 hours, CAXII-IN-3 shows melanin accumulation in porcine retinal pigment epithelium (RPE) comparable to Propranolol. |
| In vivo | CAXII-IN-3 (Compound 14) administered as a single dose (30 μL of 1% solution, eye drops) reaches peak effectiveness 120 minutes post-administration, effectively reducing intraocular pressure (IOP) in rabbits. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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