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Anti-Phospho-LIMK2 (Ser283) Polyclonal Antibody is a Rabbit antibody targeting Phospho-LIMK2 (Ser283). Anti-Phospho-LIMK2 (Ser283) Polyclonal Antibody can be used in WB,IHC-P,IF(paraffin section),ELISA.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μL | $218 | 7-10 days | |
100 μL | $316 | 7-10 days |
Description | Anti-Phospho-LIMK2 (Ser283) Polyclonal Antibody is a Rabbit antibody targeting Phospho-LIMK2 (Ser283). Anti-Phospho-LIMK2 (Ser283) Polyclonal Antibody can be used in WB,IHC-P,IF(paraffin section),ELISA. |
Ig Type | IgG |
Reactivity | Human,Mouse,Rat,Monkey |
Application | |
Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-300; ELISA: 1:5000 |
Antibody Type | Polyclonal |
Host Species | Rabbit |
Construction | Polyclonal Antibody |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Appearance | Liquid |
Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Research Background | LIM domain kinase 2(LIMK2) Homo sapiens There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008], |
Conjucates | Unconjugated |
Others Formats | Phospho |
Immunogen | A synthesized phosphopeptide: human LIMK2 around the phosphorylation site of Ser283. AA range:249-298 |
Antigen Species | human |
Uniprot ID |
Molecular Weight | Actual: 72 kDa. |
Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
Transport | Shipping with blue ice. |
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