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Anti-IL-10 Antibody (9H714) (Synonyms: TGIF, MGC126451, MGC126450, Interleukin-10, IL10A, IL-10, GVHDS, C...)
Catalog No. TMAH-00607 Copy Product Info
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Anti-IL-10 Antibody (9H714) is an antibody targeting IL-10. Anti-IL-10 Antibody (9H714) can be used in ELISA,IHC.
Anti-IL-10 Antibody (9H714)
Copy Product Info🥰Excellent
Catalog No. TMAH-00607
Synonyms TGIF, MGC126451, MGC126450, Interleukin-10, IL10A, IL-10, GVHDS, CSIF, B-TCGF
Anti-IL-10 Antibody (9H714) is an antibody targeting IL-10. Anti-IL-10 Antibody (9H714) can be used in ELISA,IHC.
Anti-IL-10 Antibody
(9H714)
(9H714)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $208 | 7-10 days | 7-10 days | |
| 100 μL | $347 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-IL-10 Antibody (9H714) is an antibody targeting IL-10. Anti-IL-10 Antibody (9H714) can be used in ELISA,IHC. |
| Synonyms | TGIF, MGC126451, MGC126450, Interleukin-10, IL10A, IL-10, GVHDS, CSIF, B-TCGF |
| Ig Type | hIgG1 |
| Clone | 9H714 |
| Reactivity | Human |
| Verified Activity | IHC image of TMAH-00607 diluted at 1:300 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Human IgG labeled by HRP and visualized using 0.05% DAB. |
| Application | |
| Recommended Dose | IHC:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Secreted. |
| Tissue Specificity | Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| Research Background | Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation. In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human IL10 Protein |
| Antigen Species | Human |
| Gene Name | IL10 |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Cancer, Immunology |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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