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ALK-IN-27

Name: ALK-IN-27
Brand: TargetMol
SKU: T83146
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T83146Cas No. 2739866-40-9

Alias NVL-655, NVL655, ALK-IN-27

Neladalkib (NVL-655) is a selective and brain-permeable ALK inhibitor with antitumor activity that inhibits a variety of ALK-mutant oncoproteins, and may be useful in the study of non-small cell cancers.

ALK-IN-27

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Purity: 99.71%

Catalog No. T83146Alias NVL-655, NVL655, ALK-IN-27Cas No. 2739866-40-9

Pack Size	Price	Availability
1 mg	$50	In Stock
5 mg	$124	In Stock
10 mg	$198	In Stock
25 mg	$365	In Stock
50 mg	$556	In Stock
1 mL x 10 mM (in DMSO)	$148	In Stock

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Batch Information

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Purity:99.71%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Neladalkib (NVL-655) is a selective and brain-permeable ALK inhibitor with antitumor activity that inhibits a variety of ALK-mutant oncoproteins, and may be useful in the study of non-small cell cancers.
Targets&IC50	Ba/F3 CLIP1-LTK cells:2.7 nM
In vitro	Neladalkib is a potent ALK inhibitor with antitumor activity. Neladalkib has an IC50 = 2.7 nM for Ba/F3 CLIP1-LTK cells.[1]
Synonyms	NVL-655, NVL655, ALK-IN-27

Chemical Properties

Molecular Weight	452.91
Formula	C₂₃H₂₂ClFN₆O
Cas No.	2739866-40-9
Smiles	C(C)N1C2=C(CC=3C(C=4C([C@@H](C)OC=5C=C2C=NC5N)=CC(F)=CC4)=NN(C)C3)C(Cl)=N1

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL(176.64 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2079 mL	11.0397 mL	22.0794 mL	110.3972 mL
5 mM	0.4416 mL	2.2079 mL	4.4159 mL	22.0794 mL
10 mM	0.2208 mL	1.1040 mL	2.2079 mL	11.0397 mL
20 mM	0.1104 mL	0.5520 mL	1.1040 mL	5.5199 mL
50 mM	0.0442 mL	0.2208 mL	0.4416 mL	2.2079 mL
100 mM	0.0221 mL	0.1104 mL	0.2208 mL	1.1040 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc