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Anti-Phospho-Gab1 (Tyr627) Polyclonal Antibody 2
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Catalog No. TMAB-10724
Anti-Phospho-Gab1 (Tyr627) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-Gab1 (Tyr627). Anti-Phospho-Gab1 (Tyr627) Polyclonal Antibody 2 can be used in WB.
Anti-Phospho-Gab1 (Tyr627) Polyclonal Antibody 2
Anti-Phospho-Gab1 (Tyr627) Polyclonal Antibody 2
Copy Product Info😃Good
Catalog No. TMAB-10724
Anti-Phospho-Gab1 (Tyr627) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-Gab1 (Tyr627). Anti-Phospho-Gab1 (Tyr627) Polyclonal Antibody 2 can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Anti-Phospho-Gab1 (Tyr627) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-Gab1 (Tyr627). Anti-Phospho-Gab1 (Tyr627) Polyclonal Antibody 2 can be used in WB. |
| Ig Type | IgG |
| Reactivity | Mouse,Rat (predicted:Human,Chicken,Dog,Pig,Cow,Horse) |
| Verified Activity | 25 μg total protein per lane of various lysates (see on figure) probed with Phospho-Gab1 (Tyr627) polyclonal antibody, unconjugated (TMAB-10724) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r. T. for 60 min. |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Gab1 is a 115 kDa multiple docking protein that plays an essential role in cellular growth, transformation and apoptosis. Gab1 can be phosphorylated by multiple receptor tyrosine kinase (RTKs), including: insulin receptor (IR), platelet derived growth factor receptor beta] (PDGFRbeta]), hepatocyte growth factor/scatter factor receptor (HGFR/SFR or c Met), and epidermal growth factor receptor (EGF), as well as in response to cell cell adhesion. Gab1 is tyrosine phosphorylated on at least 16 sites, some of which serve as binding sites for phosphoatidylinositol 3 kinase (PI3K), Grb2, PLC gamma 1, Nck, and SHP2. Phosphorylation of Gab1 on tyrosines 627 and 659 is critical for its binding to SHP2, and for activation of the ERK/MAPK pathway in response to EGF. |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human Gab1 around the phosphorylation site of Tyr627 |
| Antigen Species | Human |
| Gene Name | GAB1 |
| Gene ID | |
| Protein Name | GRB2-associated-binding protein 1 |
| Uniprot ID | |
| Function | Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). |
| Molecular Weight | Theoretical: 76 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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