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Wnt pathway inhibitor 3

Name: Wnt pathway inhibitor 3
Brand: TargetMol
SKU: T77502
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T77502Cas No. 663213-98-7

Wnt pathway inhibitor 3 is a potent AC1 inhibitor (IC50: 45 nM) with antiproliferative activity, suitable for studies to ameliorate osteoarthritis in a mouse model of experimental osteoarthritis.

Wnt pathway inhibitor 3

🥰Excellent

Purity: 99.69%

Catalog No. T77502Cas No. 663213-98-7

Wnt pathway inhibitor 3 is a potent AC1 inhibitor (IC50: 45 nM) with antiproliferative activity, suitable for studies to ameliorate osteoarthritis in a mouse model of experimental osteoarthritis.

Pack Size	Price	Availability
10 mg	$33	In Stock
25 mg	$55	In Stock
50 mg	$80	In Stock
100 mg	$119	In Stock
200 mg	$175	In Stock

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Purity:99.69%

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	Wnt pathway inhibitor 3 is a potent AC1 inhibitor (IC50: 45 nM) with antiproliferative activity, suitable for studies to ameliorate osteoarthritis in a mouse model of experimental osteoarthritis.
Targets&IC50	AC type I:45 nM
In vitro	Wnt pathway inhibitor 3 (compound 41) (0-100 μM; 72 h) exhibited anti-proliferative activity with IC50 values of 641, 470, 551, and 618 nM for HS68, Dld1, HCT116, and SW480 cells, respectively.[1]

Chemical Properties

Molecular Weight	457.27
Formula	C₂₁H₁₇BrN₂O₅
Cas No.	663213-98-7
Smiles	C(#N)C=1C(C2=C(C=C3C(=C2)OCO3)OC1N)C4=CC(OC)=C(OCC=C)C(Br)=C4
Relative Density.	1.59 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (131.21 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1869 mL	10.9345 mL	21.8689 mL	109.3446 mL
5 mM	0.4374 mL	2.1869 mL	4.3738 mL	21.8689 mL
10 mM	0.2187 mL	1.0934 mL	2.1869 mL	10.9345 mL
20 mM	0.1093 mL	0.5467 mL	1.0934 mL	5.4672 mL
50 mM	0.0437 mL	0.2187 mL	0.4374 mL	2.1869 mL
100 mM	0.0219 mL	0.1093 mL	0.2187 mL	1.0934 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc