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STAT3/AKT-IN-1
🥰Excellent
Catalog No. T209389
STAT3/AKT-IN-1 is a dual inhibitor of the signal transducer and activator of transcription 3 (STAT3) and protein kinase B (AKT) signaling pathways, demonstrating anti-tumor activity and inducing apoptosis in SGC-7901 cells.
STAT3/AKT-IN-1
STAT3/AKT-IN-1
🥰Excellent
Catalog No. T209389
STAT3/AKT-IN-1 is a dual inhibitor of the signal transducer and activator of transcription 3 (STAT3) and protein kinase B (AKT) signaling pathways, demonstrating anti-tumor activity and inducing apoptosis in SGC-7901 cells.
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Product Introduction
Bioactivity
Chemical Properties
| Description | STAT3/AKT-IN-1 is a dual inhibitor of the signal transducer and activator of transcription 3 (STAT3) and protein kinase B (AKT) signaling pathways, demonstrating anti-tumor activity and inducing apoptosis in SGC-7901 cells. |
| In vitro | STAT3/AKT-IN-1 inhibits the viability of gastric cancer cells SGC-7901 and BGC-823, with IC50 values of 1.39 μM and 2.92 μM, respectively. At concentrations ranging from 2.5 to 10 μM, STAT3/AKT-IN-1 dose-dependently induces G2/M phase cell cycle arrest, suppresses proliferation and migration of SGC-7901 cells, and triggers apoptosis. |
| In vivo | Administered intravenously at a dose of 15 mg/kg once daily for 20 days, STAT3/AKT-IN-1 demonstrates anticancer activity with no significant toxicity in SGC-7901 xenograft BALB/c mice. |
| Formula | C23H22O4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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