Powder: -20°C for 3 years | In solvent: -80°C for 1 year
12(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 12-LO. Unstimulated neutrophils metabolize 12(S)-HEPE to 12(S),20-diHEPE, whereas stimulated neutrophils produce 5(S),12(S)-HEPE via the 5-lipoxygenase pathway. The competitive action of 12(S)-HEPE with arachidonic acid as a substrate for 5-LO in the formation of leukotrienes may provide a basis for the anti-inflammatory potential of ω-3 fatty acids.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 μg | 35 days | $ 383.00 | |
50 μg | 35 days | $ 725.00 | |
100 μg | 35 days | $ 1,360.00 |
Description | 12(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 12-LO. Unstimulated neutrophils metabolize 12(S)-HEPE to 12(S),20-diHEPE, whereas stimulated neutrophils produce 5(S),12(S)-HEPE via the 5-lipoxygenase pathway. The competitive action of 12(S)-HEPE with arachidonic acid as a substrate for 5-LO in the formation of leukotrienes may provide a basis for the anti-inflammatory potential of ω-3 fatty acids. |
Molecular Weight | 318.45 |
Formula | C20H30O3 |
CAS No. | 116180-17-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
0.1 M Na2CO3: 2 mg/mL
DMF: Miscible
DMSO: Miscible
PBS (pH 7.2): 0.8 mg/mL
Ethanol: Miscible
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12(S)-HEPE 116180-17-7 12(S)HEPE 12HEPE 12(S) HEPE inhibitor inhibit