Neural Regeneration Compound Library

Catalog No. L7700

Library Compound List Excel SDF

It is well known that neurological diseases that affect the brain or other components of the central nervous system are among the most devastating and complex conditions plaguing mankind today. For thousands of years, damage to the adult central nervous system (CNS) in humans has been regarded as an ‘ailment which cannot be treated’. In the adult mammalian CNS, most injured axons do not regenerate, reflecting a major hurdle for functional recovery after trauma. Numerous efforts over more than a century have been devoted to uncover the underlying mechanisms of regeneration failure. The discovery of neural and glial precursor cells in the adult brain and their ability to grow after injury trumped this assumption. However, in most cases, only small numbers of injured CNS axons can regenerate, consistent with the idea that lack of regeneration in the adult CNS is an intrinsic property of the injured neurons. Therefore, a major challenge has been to define the underlying cellular and molecular mechanisms that determine neuronal intrinsic regenerative ability, with the goal to construct a foundation for designing therapeutic neural repair strategies.

Many signaling pathways (including Ras homolog gene/Rho-associated coiled coil-forming protein kinase (Rho-ROCK), Notch, MAPK, Wnt/β-catenin, mTOR, and ephephrin) participate in and affect repair or regeneration of neurons and axons in the central nervous system. The cyclic adenosine monophosphate-protein kinase A (cAMP-PKA) and Rho-ROCK signaling pathways are key signal transduction pathways for regulating neural and axonal regeneration.

TargetMol collects 529 compounds related to neuroregeneration as Neuroregeneration Compound Library, which can be used for screening of drugs that promote axonal growth and regeneration.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)

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please contact our compound library specialist for a customized compound library at inquiry@targetmol.com

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Product Description

A unique collection of 529 neuroregeneration related compounds for high throughput and high content screening;
Targets several signaling pathways, such as Notch, MAPK, Wnt/β-catenin, mTOR, etc.;
Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA;
Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
tructurally diverse, medicinally active, and cell permeable;
NMR and HPLC validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files

Publications Cited TargetMol Libraries

1. Cell Stem Cell. 2022 Apr 29(4) 545–558. 2. Science Bulletin. 2022. 3. Science Translational Medicine. 2022, 14(656): eabn3231. 4. Science Advances. 2023, 9(9): eade3760. 5. Nature. 2020, 582: 289-293. 6. Nature Biotechnology. 2021, 39(11): 1444-1452. 7. Nature Communications. 2022, 13(1): 1-15.. 8. Nature Communications. 2023, 14(1): 1020.. 9. Nature Communications. 2023, 14(1): 2756..

10. Blood. 2021, 137(11): 1478-1490. 11. Nucleic Acids Research. 2021. 12. Nature Communications. 2023, 14(1): 7574. 13. Advanced Science. 2020, 7(16): 2000925. 14. Angewandte Chemie. 2021. 15. Acta Pharmaceutica Sinica B. 2022. 16. Protein & Cell. 2021, 12(11): 877-888. 17. Bone Research. 2023, 11(1): 54. 18. Pharmacology & Therapeutics. (2021): 107930. 19. Nature Communications. 2021, 12(1): 1-12. 20. Journal of Cell Biology. 2022, 221(5): e202112024.

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Library Composition

PI3K (132)

mTOR (65)

Akt (56)

p38 MAPK (55)

Wnt/beta-catenin (52)

ERK (35)

DNA-PK (27)

MAPK (24)

ATM/ATR (23)

ROCK (22)

JNK (18)

Gamma-secretase (13)

NF-κB (13)

Rho (12)

PKA (9)

CDK (9)

Autophagy (9)

PKC (9)

Src (9)

S6 Kinase (8)

MEK (7)

Apoptosis (7)

AMPK (6)

PPAR (6)

VEGFR (6)

Caspase (6)

Bcr-Abl (5)

Raf (5)

STAT (4)

COX (4)

GSK-3 (4)

TGF-beta/Smad (4)

Aurora Kinase (4)

ASK (4)

PDGFR (4)

Ephrin Receptor (4)

IL Receptor (4)

HDAC (3)

FLT (3)

Glucokinase (3)

GABA Receptor (3)

Endogenous Metabolite (3)

Serine Protease (3)

Epigenetic Reader Domain (3)

DNA/RNA Synthesis (3)

c-Kit (3)

Antiviral (3)

Casein Kinase (3)

Carbonic Anhydrase (3)

TNF (3)

BCL (2)

PDK (2)

PERK (2)

Tyrosine Kinases (2)

Trk receptor (2)

ALK (2)

Antibacterial (2)

Antioxidant (2)

Porcupine (2)

PLK (2)

Beta Amyloid (2)

c-Fms (2)

c-Met/HGFR (2)

S1P Receptor (2)

Sodium Channel (2)

GRK (2)

SGK (2)

EGFR (2)

PARP (2)

Serine/threonin kinase (1)

Tie-2 (1)

PI4K (1)

Ras (1)

transporter (1)

P-gp (1)

5-HT Receptor (1)

PDE (1)

GPR (1)

ACK (1)

Adrenergic Receptor (1)

AhR (1)

Antifection (1)

Arginase (1)

Aromatase (1)

BACE (1)

BTK (1)

DHFR (1)

DNA (1)

DNA Alkylation (1)

Estrogen/progestogen Receptor (1)

FGFR (1)

Hck (1)

Parasite (1)

HCV Protease (1)

AChR (1)

HSV (1)

IGF-1R (1)

Immunology & Inflammation related (1)

Integrin (1)

IκB/IKK (1)

JAK (1)

Lipoxygenase (1)

LRRK2 (1)

MMP (1)

Nrf2 (1)

P450 (1)

HIV Protease (1)

Library Information Sample

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty