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TargetMol | Compound Library

Neural Regeneration Compound Library

Catalog No. L7700

It is well known that neurological diseases that affect the brain or other components of the central nervous system are among the most devastating and complex conditions plaguing mankind today. For thousands of years, damage to the adult central nervous system (CNS) in humans has been regarded as an ‘ailment which cannot be treated’. In the adult mammalian CNS, most injured axons do not regenerate, reflecting a major hurdle for functional recovery after trauma. Numerous efforts over more than a century have been devoted to uncover the underlying mechanisms of regeneration failure. The discovery of neural and glial precursor cells in the adult brain and their ability to grow after injury trumped this assumption. However, in most cases, only small numbers of injured CNS axons can regenerate, consistent with the idea that lack of regeneration in the adult CNS is an intrinsic property of the injured neurons. Therefore, a major challenge has been to define the underlying cellular and molecular mechanisms that determine neuronal intrinsic regenerative ability, with the goal to construct a foundation for designing therapeutic neural repair strategies. Many signaling pathways (including Ras homolog gene/Rho-associated coiled coil-forming protein kinase (Rho-ROCK), Notch, MAPK, Wnt/β-catenin, mTOR, and ephephrin) participate in and affect repair or regeneration of neurons and axons in the central nervous system. The cyclic adenosine monophosphate-protein kinase A (cAMP-PKA) and Rho-ROCK signaling pathways are key signal transduction pathways for regulating neural and axonal regeneration. TargetMol collects 524 compounds related to neuroregeneration as Neuroregeneration Compound Library, which can be used for screening of drugs that promote axonal growth and regeneration.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L7700

Neural Regeneration Compound Library
sizeIn stock
  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 524 neuroregeneration related compounds for high throughput and high content screening;
  • Targets several signaling pathways, such as Notch, MAPK, Wnt/β-catenin, mTOR, etc.;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • tructurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Packaging And Storage | TargetMol Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

Library Customization | TargetMol Library Customization

Compound Library | TargetMol
Targetmol Compound Libraries
can be highly customized!
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Library Customization | TargetMol Library Composition

PI3K
Apoptosis
Autophagy
Akt
mTOR
p38 MAPK
Wnt/beta-catenin
ERK
MAPK
ROCK
DNA-PK
ATM/ATR
NF-κB
JNK
Gamma-secretase
Endogenous Metabolite
Rho
PKC
S6 Kinase
PARP
Antibacterial
PKA
Caspase
CDK
Src
Parasite
Ras
VEGFR
Reactive Oxygen Species
Casein Kinase
MEK
AMPK
HIV Protease
COX
TNF
Antifungal
Mitophagy
Raf
DNA/RNA Synthesis
PI4K
GSK-3
BCL
IL Receptor
Beta Amyloid
STAT
HDAC
Antibiotic
Ferroptosis
PERK
PPAR
Bcr-Abl
Aurora Kinase
TGF-beta/Smad
Porcupine
Ephrin Receptor
ASK
Influenza Virus
Carbonic Anhydrase
Phosphatase
Serine Protease
Glucosidase
PDGFR
MMP
Lipoxygenase
Epigenetic Reader Domain
Interleukin
P-gp
Antiviral
PDK
GABA Receptor
P450
SGK
FLT
HCV Protease
c-Met/HGFR
Antioxidant
Adenosine Receptor
Virus Protease
Serine/threonin kinase
Calcium Channel
Adrenergic Receptor
GRK
JAK
IGF-1R
EGFR
TLR
Trk receptor
transporter
ALK
c-Fms
PLK
Cannabinoid Receptor
c-Kit
Sodium Channel
FAK
NO Synthase
ATPase
DHFR
Integrin
Estrogen/progestogen Receptor
Arginase
BACE
Lipase
RAAS
Tie-2
MRP
HBV
Tyrosine Kinases
Hck
FXR
Aryl Hydrocarbon Receptor
Immunology/Inflammation related
Topoisomerase
Myosin
PDE
Drug Metabolite
Mitochondrial Metabolism
BTK
Antifection
MAGL
DNA Alkylation
HSV
PTEN
Chk
ACK
CaMK
DNA
BCRP
Beta-Secretase
AChE
MNK
LRRK2
Nrf2
MELK
Methionine Adenosyltransferase (MAT)
IκB/IKK
Aromatase
GPR
CRISPR/Cas9
5-HT Receptor
FGFR
Potassium Channel
AhR
Kinesin
S1P Receptor

Keywords