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Ac-Exatecan

Name: Ac-Exatecan
Brand: TargetMol
SKU: T77901
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T77901Cas No. 2922852-48-8

Alias Ac-DX-8951

Ac-Exatecan (Ac-DX-8951) is acetylation-modified Exatecan.Exatecan (DX-8951) is a DNA topoisomerase I (TOP1) inhibitor with an IC50 value of 2.2 μM and antitumor activity.

Ac-Exatecan

🥰Excellent

Purity: 97.09%

Catalog No. T77901Alias Ac-DX-8951Cas No. 2922852-48-8

Ac-Exatecan (Ac-DX-8951) is acetylation-modified Exatecan.Exatecan (DX-8951) is a DNA topoisomerase I (TOP1) inhibitor with an IC50 value of 2.2 μM and antitumor activity.

Pack Size	Price	Availability
10 mg	$29	In Stock
25 mg	Preferential	In Stock
50 mg	Preferential	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Batch Information

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Purity:97.09%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Ac-Exatecan (Ac-DX-8951) is acetylation-modified Exatecan.Exatecan (DX-8951) is a DNA topoisomerase I (TOP1) inhibitor with an IC50 value of 2.2 μM and antitumor activity.
Synonyms	Ac-DX-8951

Chemical Properties

Molecular Weight	477.48
Formula	C₂₆H₂₄FN₃O₅
Cas No.	2922852-48-8
Smiles	N(C(C)=O)[C@@H]1C2=C3C(C=4N(C3)C(=O)C5=C(C4)[C@](CC)(O)C(=O)OC5)=NC=6C2=C(CC1)C(C)=C(F)C6

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (167.55 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0943 mL	10.4716 mL	20.9433 mL	104.7164 mL
5 mM	0.4189 mL	2.0943 mL	4.1887 mL	20.9433 mL
10 mM	0.2094 mL	1.0472 mL	2.0943 mL	10.4716 mL
20 mM	0.1047 mL	0.5236 mL	1.0472 mL	5.2358 mL
50 mM	0.0419 mL	0.2094 mL	0.4189 mL	2.0943 mL
100 mM	0.0209 mL	0.1047 mL	0.2094 mL	1.0472 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc