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BIIE-0246

Name: BIIE-0246
Brand: TargetMol
SKU: T14572
Rating: 4.5 (1 reviews)

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Catalog No. T14572Cas No. 246146-55-4

Alias BIIE0246, AR-H053591, AR-H 053591

BIIE-0246 is a selective NPY2R antagonist with an IC50 of 15 nM at the rat [125I]PYY3-36 site. It reduces NPY-stimulated expression of p-AKT S473 and P-p44/42 MAPK.

BIIE-0246

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Purity: 98.03%

Catalog No. T14572Alias BIIE0246, AR-H053591, AR-H 053591Cas No. 246146-55-4

BIIE-0246 is a selective NPY2R antagonist with an IC50 of 15 nM at the rat [125I]PYY3-36 site. It reduces NPY-stimulated expression of p-AKT S473 and P-p44/42 MAPK.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$69	Inquiry	Inquiry

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.03%

Appearance:Solid

Color:White

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COA MS HNMR HPLC

Product Introduction

Bioactivity

Description	BIIE-0246 is a selective NPY2R antagonist with an IC50 of 15 nM at the rat [125I]PYY3-36 site. It reduces NPY-stimulated expression of p-AKT S473 and P-p44/42 MAPK.
Targets&IC50	NPYY2 receptor:15±3 nM
In vitro	BIIE-0246 (1 µM, 24 hours) pretreatment significantly inhibited NPY-induced phosphorylation activation of Akt and MAPK in mouse podocytes [3].
In vivo	BIIE-0246 (10 μg/day, administered via intraperitoneal injection or subcutaneous osmotic minipump for 14 days) significantly reduced the urinary albumin-to-creatinine ratio (uACR) in the adriamycin nephropathy (AN) mouse model, ameliorated renal histopathological damage (such as glomerulosclerosis and reduced tubular casts), and markedly alleviated podocyte foot process effacement as confirmed by electron microscopy analysis [3].
Synonyms	BIIE0246, AR-H053591, AR-H 053591

Chemical Properties

Molecular Weight	896.05
Formula	C₄₉H₅₇N₁₁O₆
Cas No.	246146-55-4
Smiles	O=C1C=2C(C(C=3C(N1)=CC=CC3)N4CCN(C(CC5(CC(N[C@H](C(NCCN6C(=O)N(N(C6=O)C7=CC=CC=C7)C8=CC=CC=C8)=O)CCCNC(=N)N)=O)CCCC5)=O)CC4)=CC=CC2
Relative Density.	1.38 g/cm3 (Predicted)

Storage & Solubility Information

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO: ≥ 80 mg/mL, Sonication is recommended.
In Vivo Formulation	10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (3.68 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc