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RANK/TNFRSF11A Protein, Human, Recombinant (hFc)

Catalog No. TMPY-04142
Synonyms: OPTB7, OFE, OSTS, LOH18CR1, FEO, TRANCER, tumor necrosis factor receptor superfamily member 11a, TNFRSF11A, CD265, ODFR, RANK, PDB2

RANK/TNFRSF11A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.8 kDa and the accession number is Q9Y6Q6-3.

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RANK/TNFRSF11A Protein, Human, Recombinant (hFc)
Pack Size Availability Price/USD Quantity
100 μg In stock $ 451.00
200 μg 5 days $ 761.00
500 μg 5 days $ 1,510.00
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Biological Description
Technical Params
Product Properties
References and Literature
Biological Information Measured by its ability to inhibit TRANCE-induced osteoclast differentiation of RAW 264.7 mouse monocyte/macrophage cells. The ED50 for this effect is 3-16ng/mL in the presence of 5 ng/mL of TRANCE.
Description RANK/TNFRSF11A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.8 kDa and the accession number is Q9Y6Q6-3.
Species Human
Expression System HEK293 Cells
Tag C-hFc
Accession Number Q9Y6Q6-3
Synonyms OPTB7, OFE, OSTS, LOH18CR1, FEO, TRANCER, tumor necrosis factor receptor superfamily member 11a, TNFRSF11A, CD265, ODFR, RANK, PDB2
Construction The Human TNFRSF11A (NP_001257879.1) (Met1-Pro212) was expressed with the Fc region of Human IgG1 at the C-terminus.
Protein Purity > 90 % as determined by SDS-PAGE
Molecular Weight 46.8 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. It is an essential mediator for osteoclast and lymph node development. TNFRSF11A and its ligand are important regulators of the interaction between T cells and dendritic cells. It can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. Defects in TNFRSF11A can cause familial expansile osteolysis (FEO). FEO is a rare autosomal dominant bone disorder characterized by focal areas of increased bone remodeling. Defects in TNFRSF11A also can cause Paget disease of bone type 2 (PDB2). PDB2 is a bone-remodeling disorder with clinical similarities to FEO. Defects in TNFRSF11A are the cause of osteopetrosis autosomal recessive type 7 which characterized by abnormally dense bone, due to defective resorption of immature bone.

References and Literature

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Keywords

RANK/TNFRSF11A Protein, Human, Recombinant (hFc) OPTB7 PDB-2 OFE PDB 2 OSTS LOH18CR1 FEO OPTB-7 TRANCER OPTB 7 tumor necrosis factor receptor superfamily member 11a CD-265 TNFRSF11A CD265 ODFR CD 265 RANK PDB2 recombinant recombinant-proteins proteins protein

 

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