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Anti-BCL-XL Antibody (1J99)
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Catalog No. TMAH-00110
Alias PPP1R52, bcl-xS, BCLXS, BCL-XL/S, bcl-xL, BCLXL, Bcl-X, BCLX, BCL2-like 1, BCL2L
Anti-BCL-XL Antibody (1J99) is a Mouse antibody targeting BCL-XL. Anti-BCL-XL Antibody (1J99) can be used in ELISA, WB, IHC.
Anti-BCL-XL Antibody (1J99)
Anti-BCL-XL Antibody (1J99)
😃Good
Catalog No. TMAH-00110Alias PPP1R52, bcl-xS, BCLXS, BCL-XL/S, bcl-xL, BCLXL, Bcl-X, BCLX, BCL2-like 1, BCL2L
Anti-BCL-XL Antibody (1J99) is a Mouse antibody targeting BCL-XL. Anti-BCL-XL Antibody (1J99) can be used in ELISA, WB, IHC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μg | $207 | 7-10 days | |
| 100 μg | $349 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: ELISA, WB, IHC Reactivity: Human |
| Alias | PPP1R52, bcl-xS, BCLXS, BCL-XL/S, bcl-xL, BCLXL, Bcl-X, BCLX, BCL2-like 1, BCL2L |
| Ig Type | IgG1 |
| Clone | 1J99 |
| Reactivity | Human |
| Verified Activity | 1. Immunohistochemical of paraffin-embedded Human endometrium tissue using TMAH-00110 at dilution of 1:200 2. Immunohistochemical of paraffin-embedded Human Colon cancer tissue using TMAH-00110 at dilution of 1:200 3. Western Blot -All lanes:Mouse anti BCL2L1 Monoclonal antibody at 1μg/ml -Lane 1:HepG2 whole cell lysate -Secondary Goat polyclonal to Mouse IgG at 1/5000 dilution -Predicted band size:26,27,19kd -Observed band size:26KD |
| Application | ELISA, WB, IHC |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | [Isoform Bcl-X(L)]: Mitochondrion inner membrane. Mitochondrion outer membrane. Mitochondrion matrix. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side. |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein G purified |
| Appearance | Liquid |
| Formulation | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| Purity | >95% |
| Research Background | Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release. Isoform Bcl-X(S) promotes apoptosis. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human Bcl-2-like Protein 1 Protein |
| Antigen Species | Human |
| Gene ID | 598 |
| Uniprot ID | |
| Biology Area | Cell Biology |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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