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Anti-BCL-XL Antibody (1J99)
(Synonyms: PPP1R52, bcl-xS, BCLXS, BCL-XL/S, bcl-xL, BCLXL, Bcl-X, BCLX, BCL2-like 1, BCL2L) Copy Product Info
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Synonyms: PPP1R52, bcl-xS, BCLXS, BCL-XL/S, bcl-xL, BCLXL, Bcl-X, BCLX, BCL2-like 1, BCL2L
Catalog No. TMAH-00110 Copy Product Info
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Anti-BCL-XL Antibody (1J99) is a Mouse antibody targeting BCL-XL. Anti-BCL-XL Antibody (1J99) can be used in ELISA,IHC,WB.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μg | $207 | 7-10 days | 7-10 days | |
| 100 μg | $349 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Chemical Properties
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| Description | Anti-BCL-XL Antibody (1J99) is a Mouse antibody targeting BCL-XL. Anti-BCL-XL Antibody (1J99) can be used in ELISA,IHC,WB. |
| Synonyms | PPP1R52, bcl-xS, BCLXS, BCL-XL/S, bcl-xL, BCLXL, Bcl-X, BCLX, BCL2-like 1, BCL2L |
| Ig Type | IgG1 |
| Clone | 1J99 |
| Reactivity | Human |
| Application | |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | [Isoform Bcl-X(L)]: Mitochondrion inner membrane. Mitochondrion outer membrane. Mitochondrion matrix. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side. |
| Tissue Specificity | Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain. |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein G purified |
| Appearance | Liquid |
| Formulation | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| Purity | >95% |
| Research Background | Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release. Isoform Bcl-X(S) promotes apoptosis. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human Bcl-2-like Protein 1 Protein |
| Antigen Species | Human |
| Gene Name | BCL2L1 |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Cell Biology |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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